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Showing 1–5 of 5 results
Advanced filters: Author: Deepak Ramanujam Clear advanced filters

  • Macrophages are increasingly recognized as key drivers of lung damage in acute pneumonia including COVID-19. Here, the authors report on a first-in-class, inhalable, carbohydrate-coupled microRNA-inhibitor for selective targeting of macrophages and that prevents pulmonary hyperinflammation.

    • Christina Beck
    • Deepak Ramanujam
    • Stefan Engelhardt
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Muscle cells express an adhesion molecule called metavinculin, which has been associated with cardiomyopathies. Here, the authors employed molecular tension sensors to reveal that metavinculin expression modulates cell adhesion mechanics and they develop a mouse model to demonstrate that the presence of metavinculin is not as critical for heart muscle function as previously thought.

    • Verena Kanoldt
    • Carleen Kluger
    • Carsten Grashoff
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • An abnormal cardiac action potential underlies different types of cardiac arrhythmias. Here the authors show that microRNA-365 regulates the cardiac action potential by modulating key cardiac repolarizing channels.

    • Dena Esfandyari
    • Bio Maria Ghéo Idrissou
    • Stefan Engelhardt
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • MicroRNA-29 is known to reduce collagen production in fibroblasts thereby inhibiting fibrosis in various organs. Here, Sassi et al. show that miR-29 can also enhance fibrotic signalling and pathological hypertrophy of the heart through its action in cardiomyocytes.

    • Yassine Sassi
    • Petros Avramopoulos
    • Stefan Engelhardt
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11