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Showing 1–3 of 3 results
Advanced filters: Author: Deeptak Verma Clear advanced filters

  • Expanding the biocatalysis toolbox for C–N bond formation is of great value. Now, a biocatalytic amination strategy using a new-to-nature mechanism involving nitrogen-centred radicals has been developed. The transformations are enabled by synergistic photoenzymatic catalysis, providing intra- and intermolecular hydroamination products with high yields and levels of enantioselectivity.

    • Yuxuan Ye
    • Jingzhe Cao
    • Todd K. Hyster
    Research
    Nature Chemistry
    Volume: 15, P: 206-212

  • Leveraging enzymatic selectivity, a single reaction stream provides a single diastereomer of the cyclic dinucleotide MK-1454, a promising immune-oncology drug candidate, without the use of protecting groups or chiral auxiliaries.

    • John A. McIntosh
    • Zhijian Liu
    • Matthew L. Maddess
    Research
    Nature
    Volume: 603, P: 439-444

  • A solid-phase glycan remodeling (SPGR) platform is presented. Over thirty enzymes were evaluated for successive glycoengineering of immobilized antibodies with outstanding performance in several SPGR reactions.

    • Yen-Pang Hsu
    • Deeptak Verma
    • Benjamin F. Mann
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-11