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Showing 1–5 of 5 results
Advanced filters: Author: Deepti Talwar Clear advanced filters

  • Mercaptopyruvate sulfur transferase (MPST) is revealed as a protein persulfidase that acts directly on numerous and diverse target proteins, revealing potential origins of persulfidation as a common posttranslational modification.

    • Brandán Pedre
    • Deepti Talwar
    • Tobias P. Dick
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 19, P: 507-517

  • LC3-associated phagocytosis (LAP) is a non-canonical use of the autophagy machinery that can contribute to immune responses. Here, the authors describe the mechanism by which ROS production regulates LAPosome stabilization sustaining MHC II dependent antigen presentation.

    • Laure-Anne Ligeon
    • Maria Pena-Francesch
    • Christian Münz
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Peroxiredoxin 2 (Prx2) was previously shown to transfer H2O2-derived oxidative equivalents to STAT3, generating disulfide-linked dimers and tetramers. Here the authors show that the interaction between Prx2 and STAT3 at the plasma membrane is mediated by the membrane chaperone annexin A2; suggesting that the redox relay complex is part of a membrane signaling domain.

    • Deepti Talwar
    • Joris Messens
    • Tobias P. Dick
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • A redox relay was identified in mammalian cells where the H2O2-reactive protein peroxiredoxin-2 oxidizes the transcription factor STAT3, resulting in the formation of transcriptionally inactive disulfide-linked oligomers.

    • Mirko C Sobotta
    • Willy Liou
    • Tobias P Dick
    Research
    Nature Chemical Biology
    Volume: 11, P: 64-70