Nature Search

Deep learning-based phenotyping reclassifies combined hepatocellular-cholangiocarcinoma

Combined hepatocellular-cholangiocarcinomas (cHCC-CCA) are challenging to diagnose, as they exhibit features of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICCA). Here, the authors use deep learning to re-classify cHCC-CCA tumours into HCC or ICCA based on histopathology images.

Julien Calderaro
Narmin Ghaffari Laleh
Jakob Nikolas Kather
ResearchOpen Access14 Dec 2023
Nature Communications

Volume: 14, P: 1-10
Author Correction: Rapid gate-based spin read-out in silicon using an on-chip resonator

Guoji Zheng
Nodar Samkharadze
Lieven M. K. Vandersypen
Amendments and Corrections25 Nov 2019
Nature Nanotechnology

Volume: 14, P: 1170
Rapid gate-based spin read-out in silicon using an on-chip resonator

The spin state of electrons in a double quantum dot in silicon is read in a single shot with 98% average fidelity within 6 μs by means of an on-chip superconducting resonator connected to two of the gates defining the double dot structure.

Guoji Zheng
Nodar Samkharadze
Lieven M. K. Vandersypen
Research08 Jul 2019
Nature Nanotechnology

Volume: 14, P: 742-746
Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity

EpCAM is an unconventional epithelia-specific cell–cell adhesion molecule, that is mutated in the majority of cases of Congenital Tufting Enteropathy. Here the authors show that loss of EpCAM causes a concentration of contractile activity at tricellular junctions, leading to aberrant apical domain and tight junction displacement.

Julie Salomon
Cécile Gaston
Delphine Delacour
ResearchOpen Access13 Jan 2017
Nature Communications

Volume: 8, P: 1-18
Universal control of a six-qubit quantum processor in silicon

The universal control of six qubits in a ²⁸Si/SiGe quantum dot array is demonstrated, achieving Rabi oscillations for each qubit with visibilities of 93.5–98.0%, implying high readout and initialization fidelities.

Stephan G. J. Philips
Mateusz T. Mądzik
Lieven M. K. Vandersypen
ResearchOpen Access28 Sept 2022
Nature

Volume: 609, P: 919-924
Long-term outcome of imatinib 400 mg compared to imatinib 600 mg or imatinib 400 mg daily in combination with cytarabine or pegylated interferon alpha 2a for chronic myeloid leukaemia: results from the French SPIRIT phase III randomised trial

Francois Guilhot
Françoise Rigal-Huguet
Franck-Emmanuel Nicolini
Research22 Jan 2021
Leukemia

Volume: 35, P: 2332-2345
Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Known genetic loci account for only a fraction of the genetic contribution to Alzheimer’s disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy of an Alzheimer’s disease polygenic risk score.

Itziar de Rojas
Sonia Moreno-Grau
Agustín Ruiz
ResearchOpen Access07 Jun 2021
Nature Communications

Volume: 12, P: 1-16
Allele variations in the OCA2 gene (pink-eyed-dilution locus) are associated with genetic susceptibility to melanoma

Anne-Sophie Jannot
Roubila Meziani
Melan-Cohort
Research27 Apr 2005
European Journal of Human Genetics

Volume: 13, P: 913-920
ACOX1-mediated peroxisomal fatty acid oxidation contributes to metabolic reprogramming and survival in chronic lymphocytic leukemia

Mariana Tannoury
Marianne Ayoub
Santos A. Susin
Research06 Dec 2023
Leukemia

Volume: 38, P: 302-317
Antimicrobial protein REG3A regulates glucose homeostasis and insulin resistance in obese diabetic mice

Antimicrobial protein REG3A improved insulin sensitivity by combating oxidative stress and activating AMPK in skeletal muscle in HFD-induced obese mice overexpressing human REG3A in the liver.

Patrick Gonzalez
Alexandre Dos Santos
Jamila Faivre
ResearchOpen Access15 Mar 2023
Communications Biology

Volume: 6, P: 1-17
Assessing respiratory epidemic potential in French hospitals through collection of close contact data (April–June 2020)

George Shirreff
Bich-Tram Huynh
Didier Guillemot
ResearchOpen Access14 Feb 2024
Scientific Reports

Volume: 14, P: 1-11
Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Itziar de Rojas
Sonia Moreno-Grau
Agustín Ruiz
Amendments and CorrectionsOpen Access09 Feb 2023
Nature Communications

Volume: 14, P: 1-2
Sinusoidal obstruction syndrome: a warning about autologous stem cell transplantation preceded by regimens containing oxaliplatin

Pierre-Edouard Debureaux
Delphine Le Febvre de Nailly
Jehan Dupuis
Correspondence20 Jan 2020
Bone Marrow Transplantation

Volume: 55, P: 1834-1836

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Deep learning-based phenotyping reclassifies combined hepatocellular-cholangiocarcinoma

Author Correction: Rapid gate-based spin read-out in silicon using an on-chip resonator

Rapid gate-based spin read-out in silicon using an on-chip resonator

Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity

Universal control of a six-qubit quantum processor in silicon

Long-term outcome of imatinib 400 mg compared to imatinib 600 mg or imatinib 400 mg daily in combination with cytarabine or pegylated interferon alpha 2a for chronic myeloid leukaemia: results from the French SPIRIT phase III randomised trial

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Allele variations in the OCA2 gene (pink-eyed-dilution locus) are associated with genetic susceptibility to melanoma

ACOX1-mediated peroxisomal fatty acid oxidation contributes to metabolic reprogramming and survival in chronic lymphocytic leukemia

Antimicrobial protein REG3A regulates glucose homeostasis and insulin resistance in obese diabetic mice

Assessing respiratory epidemic potential in French hospitals through collection of close contact data (April–June 2020)

Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Sinusoidal obstruction syndrome: a warning about autologous stem cell transplantation preceded by regimens containing oxaliplatin

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