Restricting hypertrophic heart growth in response to pathologic overload is an unmet therapeutic need. Here, the authors show that blocking Ca2+signaling controlled by the transport protein PMCA4 in cardiac fibroblasts enhances secretion of a potent Wnt signaling inhibitor, sFRP2, and prevents the development of pathologic cardiac hypertrophy in mice.
- Tamer M. A. Mohamed
- Riham Abou-Leisa
- Delvac Oceandy
