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Showing 1–4 of 4 results
Advanced filters: Author: Delyth M. Reid Clear advanced filters

  • How MICL recognizes and autoregulates the formation of neutrophil extracellular traps is explored in mouse models and human patients where disease severity is associated with aberrant neutrophil extracellular trap formation.

    • Mariano Malamud
    • Lauren Whitehead
    • Gordon D. Brown
    ResearchOpen Access
    Nature
    Volume: 633, P: 442-450

  • Complement components activate and recruit immune cells, promoting host defense and inflammatory disease. Jörg Köhl and his colleagues demonstrate that IgG1 immune complexes inhibit C5a-mediated inflammatory responses and disease. The inhibitory effect of IgG1 immune complexes requires galactosylation of the antibody, binding to the inhibitory IgG receptor FcγRIIB and the association of FcγRIIB with the C-type lectin–like receptor dectin-1.

    • Christian M Karsten
    • Manoj K Pandey
    • Jörg Köhl
    Research
    Nature Medicine
    Volume: 18, P: 1401-1406