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Showing 1–12 of 12 results
Advanced filters: Author: Dena B. Dubal Clear advanced filters

  • As Nature Aging celebrates its fifth anniversary, the journal asks some of the researchers who contributed to the journal early on to reflect on the past and the future of aging and age-related disease research, the impact of the field on human health now and in the future, and what challenges need to be addressed to ensure sustained progress.

    • Fabrisia Ambrosio
    • Maxim N. Artyomov
    • Sebastien Thuault
    Comments & Opinion
    Nature Aging
    Volume: 6, P: 6-22

  • Dena B. Dubal is a physician–scientist and the endowed chair in aging and neurodegenerative disease in the neurology department at the University of California, San Francisco. She has received awards from the National Institutes of Health and American Federation for Aging Research.

    • Dena B. Dubal
    Comments & Opinion
    Nature Medicine
    Volume: 25, P: 1027

  • Cheng and colleagues propose a mechanism for amyloid-β toxicity that may have relevance for Alzheimer's disease. They show that Aβ1–42 induces expression of collagen VI and that collagen VI protects against Aβ toxicity in cultured neurons.

    • Jason S Cheng
    • Dena B Dubal
    • Lennart Mucke
    Research
    Nature Neuroscience
    Volume: 12, P: 119-121

  • This Case Study describes a 63-year-old woman with a history of metastatic breast cancer who presented with rapidly progressing myelopathic symptoms and an elevated titer for the neuromyelitis optic antibody. The appearance of myelopathy correlated with recurrence of the patient's breast cancer on two separate occasions, and the authors suggest this case represents a possible paraneoplastic syndrome associated with the neuromyelitis antibody.

    • Sabine Mueller
    • Dena B Dubal
    • S Andrew Josephson
    Reviews
    Nature Clinical Practice Neurology
    Volume: 4, P: 284-288

  • Cognitive dysfunction in aging is a major biomedical challenge without medical therapies. Here, Castner et al. show that longevity factor klotho enhances cognition in aged nonhuman primates, increasing its relevance for a therapeutic path to humans.

    • Stacy A. Castner
    • Shweta Gupta
    • Dena B. Dubal
    ResearchOpen Access
    Nature Aging
    Volume: 3, P: 931-937

  • Sex modifies Alzheimer’s Disease vulnerability, but the reasons for this are largely unknown. Here, the authors utilize two independent electronic medical record systems to perform deep clinical phenotyping and network analysis to gain insight into clinical characteristics and sex-specific clinical associations.

    • Alice S. Tang
    • Tomiko Oskotsky
    • Marina Sirota
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • It is shown that amyloid-β oligomers interact with the receptor tyrosine kinase EphB2 and trigger its degradation. EphB2 regulates NMDA-type glutamate receptors and its depletion in normal mice reduces NMDA receptor currents and impairs long-term potentiation, both of which are important for memory formation. Increasing EphB2 levels in a mouse model of Alzheimer's disease improves memory.

    • Moustapha Cissé
    • Brian Halabisky
    • Lennart Mucke
    Research
    Nature
    Volume: 469, P: 47-52

  • The authors show that astrocytes produce high levels of the adenosine receptor A2A in Alzheimer brains. Reducing the levels of astrocytic A2A boosted memory in young and aging mice and mouse models of Alzheimer disease, whereas activating a related molecular pathway impaired memory. Thus, astrocytes regulate memory and abnormal receptor activity in these cells may contribute to memory disorders.

    • Anna G Orr
    • Edward C Hsiao
    • Lennart Mucke
    Research
    Nature Neuroscience
    Volume: 18, P: 423-434