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Showing 1–2 of 2 results
Advanced filters: Author: Denis Bartoschek Clear advanced filters

  • Molecular glue degraders (MGD) offer a way to target undruggable proteins, but their discovery is challenging. Here, the authors develop a high-throughput proteomics platform for MGD drug discovery, revealing a much larger cereblon neosubstrate space than initially thought.

    • Martin Steger
    • Gisele Nishiguchi
    • Zoran Rankovic
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • This work compares the preclinical lung biodistribution and efficacy profile of inhaled anti-CCN2 (cellular communication network factor 2) Anticalin® protein PRS-220 for the treatment for idiopathic pulmonary fibrosis (IPF) compared to systemic delivery of a CCN2 inhibitor.

    • Vanessa Neiens
    • Eva-Maria Hansbauer
    • Marina Pavlidou
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20