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Showing 1–7 of 7 results
Advanced filters: Author: Denis Bucher Clear advanced filters

  • Fragment screening by X-ray crystallography is challenging for membrane proteins, especially when crystals are grown in lipid cubic phase (LCP). Here, the authors establish a large-scale fragment screening approach integrating high-throughput LCP crystallography with computational and biophysical methods to identify ligands for adenosine A2A receptor.

    • Chia-Ying Huang
    • Robert Cheng
    • May Sharpe
    ResearchOpen Access
    Communications Chemistry
    P: 1-12

  • By performing a CAR-adapted base-editing screen of phosphatidylinositol-3-kinase delta (PI3Kδ, PIK3CD), Bucher et al. identify mutations affecting endogenous PI3K–AKT signaling that enhances CAR T cell antitumor potency.

    • Philip Bucher
    • Nadine Brückner
    • Josef Leibold
    ResearchOpen Access
    Nature Cancer
    Volume: 7, P: 368-383

  • Lateral opening of the LptDE transporter in the outer membrane of Gram-negative bacteria is necessary for insertion of lipopolysaccharides. Here, Botte et al. report a cryo-EM structure of a partially opened LptDE transporter, in complex with rigid chaperones derived from nanobodies.

    • Mathieu Botte
    • Dongchun Ni
    • Michael Hennig
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • The beetle Tribolium castaneum is a commonly used laboratory model, combining the ease of systematic RNAi experiments like those in Caenorhabditis elegans, with biology that is more representative of most insects than Drosophila melanogaster. A large consortium has sequenced and analysed the genome of the red flour beetle, creating a resource for biologists everywhere.

    • Stephen Richards
    • Richard A. Gibbs
    • Gregor Bucher
    ResearchOpen Access
    Nature
    Volume: 452, P: 949-955

  • Etrumadenant has been developed as a dual-acting adenosine A2A/A2B receptor antagonist, and is now in clinical trials for the treatment of cancer, however, the exact drug–receptor binding mode is unknown. Here, the authors determine the high-resolution co-crystal structure of Etrumadenant with a thermostabilized A2AAR construct and reveal the interaction of its cyano group with T883.36.

    • Tobias Claff
    • Jonathan G. Schlegel
    • Christa E. Müller
    ResearchOpen Access
    Communications Chemistry
    Volume: 6, P: 1-10

  • The imminent release of tissue atlases combining multichannel microscopy with single-cell sequencing and other omics data from normal and diseased specimens creates an urgent need for data and metadata standards to guide data deposition, curation and release. We describe a Minimum Information about Highly Multiplexed Tissue Imaging (MITI) standard that applies best practices developed for genomics and for other microscopy data to highly multiplexed tissue images and traditional histology.

    • Denis Schapiro
    • Clarence Yapp
    • Peter K. Sorger
    Comments & Opinion
    Nature Methods
    Volume: 19, P: 262-267