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Showing 1–3 of 3 results
Advanced filters: Author: Deniz Gökbuget Clear advanced filters
  • MicroRNAs are known to regulate myelination in the peripheral nervous system, but the underlying mechanisms remain unclear. Here the authors show that the Lin28B/let-7 axis drives the onset of myelination by promoting Krox20 expression through suppression of Notch signalling.

    • Deniz Gökbuget
    • Jorge A. Pereira
    • Ueli Suter
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-9
  • Goekbuget et al. characterize the role of the developmentally essential transcriptional repressor FOXD3 in limiting transcription of highly active genes upon entry into S phase to promote faithful DNA replication and to protect genome integrity.

    • Deniz Gökbuget
    • Kayla Lenshoek
    • Robert Blelloch
    Research
    Nature Structural & Molecular Biology
    Volume: 30, P: 1561-1570
  • Molecular engineering allows stoichiometric and co-localized expression of two optogenetic actuators, spaced by a fluorescent protein and an additional transmembrane helix in a single protein fusion. The method provides modular optogenetic tools for bidirectional membrane potential control or synergistic effects on neuronal activity.

    • Sonja Kleinlogel
    • Ulrich Terpitz
    • Ernst Bamberg
    Research
    Nature Methods
    Volume: 8, P: 1083-1088