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Showing 1–5 of 5 results
Advanced filters: Author: Denzel R. D. Cruz Clear advanced filters

  • During microbial infection, proteins are modified by the ubiquitin-like protein ISG15. Here, the authors uncover RNF213 as a sensor for ISGylated proteins on the surface of lipid droplets, showing that RNF213 has antiviral properties but also directly targets intracellular bacteria in infected cells.

    • Fabien Thery
    • Lia Martina
    • Francis Impens
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-21

  • The intracellular fragment of the adhesion molecule EpCAM, which is generated by the proteases TACE and presenilin-2, increases cell proliferation and acts in a complex with β-catenin and Lef-1 to regulate gene expression.

    • Dorothea Maetzel
    • Sabine Denzel
    • Olivier Gires
    Research
    Nature Cell Biology
    Volume: 11, P: 162-171

  • Inhibitors of mitochondrial transcription that target human mitochondrial RNA polymerase provide a chemical biology tool for studying the role of mitochondrial DNA expression in a wide range of pathologies.

    • Nina A. Bonekamp
    • Bradley Peter
    • Nils-Göran Larsson
    Research
    Nature
    Volume: 588, P: 712-716

  • Rhee, Pokrovskaya et al. utilize 3D electron microscopy of mouse jugular vein puncture wounds to reveal thrombi structured around localized, nucleated platelet aggregates that produced a vaulted thrombus capped by extravascular platelet adherence. As a result, the authors propose a “Cap and Build” paradigm of primary hemostasis.

    • Sung W. Rhee
    • Irina D. Pokrovskaya
    • Brian Storrie
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-13