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The Mll2 branch of the COMPASS family regulates bivalent promoters in mouse embryonic stem cells

Embryonic stem cells (ESCs) possess a unique chromatin landscape in which 'bivalent' domains of trimethylated histone H3 Lys4 (H3K4me3) and Lys27 (H3K27me3) mark key lineage-specific genes. A new study now reports the identification of Mll2 (KMT2b) as the enzyme responsible for implementing H3K4me3 on bivalently marked promoters in ESCs.

Deqing Hu
Alexander S Garruss
Ali Shilatifard
Research11 Aug 2013
Nature Structural & Molecular Biology

Volume: 20, P: 1093-1097
Oxidative decomposition mechanisms of lithium carbonate on carbon substrates in lithium battery chemistries

Lithium carbonate is ubiquitous in lithium battery chemistries and leads to overpotentials, however its oxidative decomposition is unclear. Here, the authors study its decomposition in ether electrolyte, clarify the role of the carbon substrate, and propose a route to limit released singlet oxygen.

Deqing Cao
Chuan Tan
Yuhui Chen
ResearchOpen Access20 Aug 2022
Nature Communications

Volume: 13, P: 1-12
Impact of red blood cell transfusion in massive burn: a multicenter cohort study

Yong Du
Yilan Xia
Chunmao Han
ResearchOpen Access20 Feb 2025
Scientific Reports

Volume: 15, P: 1-9
tRNA m¹A modification regulate HSC maintenance and self-renewal via mTORC1 signaling

Haematopoietic stem cells (HSCs) rely on tightly controlled protein translation to sustain blood production and respond to stress. Here, the authors uncover that TRMT6-TRMT61A proteins regulate HSC function by modifying tRNA, which fine-tunes mTORC1 signaling and thus translation.

Hongna Zuo
Aiwei Wu
Hu Wang
ResearchOpen Access08 Jul 2024
Nature Communications

Volume: 15, P: 1-13
Enhancer decommissioning by MLL4 ablation elicits dsRNA-interferon signaling and GSDMD-mediated pyroptosis to potentiate anti-tumor immunity

The role of enhancer de-regulation in anti-tumor immunity remains to be explored. Here, the authors suggest that ablation of MLL3 and MLL4, two enhancer-associated H3K4 monomethyltransferases, increases tumor immunogenicity and promotes anti-tumor T cell response.

Hanhan Ning
Shan Huang
Deqing Hu
ResearchOpen Access02 Nov 2022
Nature Communications

Volume: 13, P: 1-20
Comparative analysis of long noncoding RNA and mRNA expression provides insights into adaptation to hypoxia in Tibetan sheep

Fan Wang
Jianbin Liu
Deqing Zhuoga
ResearchOpen Access21 Apr 2022
Scientific Reports

Volume: 12, P: 1-15
PRMT2 promotes HIV-1 latency by preventing nucleolar exit and phase separation of Tat into the Super Elongation Complex

The mechanisms regulating Tat function for HIV-1 replication remain poorly understood. Here, the authors reveal that the transcriptional activity of Tat is modulated by a PRMT2-licensed switch between its nucleolar sequestration and phase separation into the nucleoplasmic Super Elongation Complex (SEC) droplets.

Jiaxing Jin
Hui Bai
Deqing Hu
ResearchOpen Access10 Nov 2023
Nature Communications

Volume: 14, P: 1-18
TmcA functions as a lysine 2-hydroxyisobutyryltransferase to regulate transcription

RNA acetyltransferase TmcA functions as a lysine 2-hydroxyisobutyryltransferase to regulate bacterial transcription in response to acid stress in prokaryotes.

Hanyang Dong
Yujie Zhao
Kai Zhang
Research13 Dec 2021
Nature Chemical Biology

Volume: 18, P: 142-151
Promoter bivalency favors an open chromatin architecture in embryonic stem cells

Analysis of bivalent promoters in embryonic stem cells (ESCs) shows that deletion of MLL2 in ESCs leads to increased Polycomb occupancy, reduced promoter accessibility, redistribution of long-range chromatin interactions, and failure to differentiate.

Glòria Mas
Enrique Blanco
Luciano Di Croce
Research17 Sept 2018
Nature Genetics

Volume: 50, P: 1452-1462
The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development

Two studies demonstrate that the methyltransferase KMT2D, which is recurrently mutated in several types of human B cell lymphoma, suppresses tumorigenesis by altering the epigenetic landscape of B cells; Kmt2d deletion in mice perturbs normal B cell development.

Ana Ortega-Molina
Isaac W Boss
Hans-Guido Wendel
Research14 Sept 2015
Nature Medicine

Volume: 21, P: 1199-1208
Phase separation of MRG15 delays cellular senescence

Intrinsically disordered region (IDR)-driven liquid-liquid phase separation of MRG15 orchestrates the senescence process of human mesenchymal stem cells.

Yuwen Li
Xinrong Jin
Hu Wang
ResearchOpen Access01 May 2025
Communications Biology

Volume: 8, P: 1-10
Comparative single-cell analysis reveals heterogeneous immune landscapes in adenocarcinoma of the esophagogastric junction and gastric adenocarcinoma

Jierong Chen
Qunsheng Huang
Yong Li
ResearchOpen Access05 Jan 2024
Cell Death & Disease

Volume: 15, P: 1-11
Author Correction: Suppression of m⁶A reader Ythdf2 promotes hematopoietic stem cell expansion

Zhenrui Li
Pengxu Qian
Linheng Li
Amendments and Corrections27 Aug 2018
Cell Research

Volume: 28, P: 1042
Suppression of m⁶A reader Ythdf2 promotes hematopoietic stem cell expansion

Zhenrui Li
Pengxu Qian
Linheng Li
Research31 Jul 2018
Cell Research

Volume: 28, P: 904-917
Reverse-migrated neutrophils regulated by JAM-C are involved in acute pancreatitis-associated lung injury

Deqing Wu
Yue Zeng
Guoyong Hu
ResearchOpen Access04 Feb 2016
Scientific Reports

Volume: 6, P: 1-15
A Carcinogen-induced mouse model recapitulates the molecular alterations of human muscle invasive bladder cancer

Damiano Fantini
Alexander P. Glaser
Joshua J. Meeks
ResearchOpen Access25 Jan 2018
Oncogene

Volume: 37, P: 1911-1925
YTHDC1-mediated microRNA maturation is essential for hematopoietic stem cells maintenance

Hongna Zuo
Jin Liu
Hu Wang
ResearchOpen Access16 Oct 2024
Cell Death Discovery

Volume: 10, P: 1-13
Microstructure and domain engineering of lithium niobate crystal films for integrated photonic applications

Dehui Sun
Yunwu Zhang
Hong Liu
ReviewsOpen Access10 Dec 2020
Light: Science & Applications

Volume: 9, P: 1-18

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