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Showing 1–5 of 5 results
Advanced filters: Author: Derek Blankenship Clear advanced filters

  • Congenital CMV infection can result in sensorineural hearing loss, but predicting this outcome is not yet possible. Here, the authors show that while blood gene expression profiles are not substantially different between symptomatic and asymptomatic infants with congenital CMV infection, a 16-gene signature is identified and able to predict late-onset hearing loss in these children.

    • Christopher P. Ouellette
    • Pablo J. Sánchez
    • Asuncion Mejias
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • The effects of vaccines on human dendritic cells (DCs) are incompletely understood. Here the authors build a transcriptional modular network based on in vitroinfection of human DCs and apply it for the characterization of the DC response to 13 different vaccines.

    • Romain Banchereau
    • Nicole Baldwin
    • Virginia Pascual
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-14

  • Recently triggered seismic events such as the Pohang earthquake have exceeded predictions of average energy releases by a factor of 1000. A new framework is proposed to define maximum event magnitudes as a function of pre-existing critical stresses and fluid injection volume.

    • Ziyan Li
    • Derek Elsworth
    • M. W. McClure
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • Here, the human immune response to infection with Mycobacterium tuberculosis has been characterized by transcriptional profiling. The results show that active tuberculosis correlates with a particular transcriptional signature that is dominated by a neutrophil-driven interferon-inducible gene profile. The study provides a broad range of transcriptional biomarkers with potential as diagnostic and prognostic tools to combat the tuberculosis epidemic.

    • Matthew P. R. Berry
    • Christine M. Graham
    • Anne O’Garra
    Research
    Nature
    Volume: 466, P: 973-977