Nature Search

Mapping the genetic landscape across 14 psychiatric disorders

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Andrew D. Grotzinger
Josefin Werme
Jordan W. Smoller
ResearchOpen Access10 Dec 2025
Nature

Volume: 649, P: 406-415
A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
Distinct ossification trade-offs illuminate the shoulder girdle reconfiguration at the water-to-land transition

Gli and Hedgehog genes compound knockout fish exhibited a combination of actinopterygian fish and stem-tetrapod pectoral girdle characteristics, suggesting the evolutionary origin of terrestrial girdles as a tuning of a deeply conserved developmental program.

Janet Wei
Thomas W. P. Wood
Tetsuya Nakamura
ResearchOpen Access29 May 2025
Nature Communications

Volume: 16, P: 1-16
Mucosal-associated invariant T cells restrict reactive oxidative damage and preserve meningeal barrier integrity and cognitive function

Yang and colleagues report that MAIT cells are present in the meninges where they play an essential role in repressing tissue ROS accumulation and preserving meningeal barrier integrity.

Yuanyue Zhang
Jacob T. Bailey
Qi Yang
Research21 Nov 2022
Nature Immunology

Volume: 23, P: 1714-1725
TCRα-TCRβ pairing controls recognition of CD1d and directs the development of adipose NKT cells

Sant’Angelo and colleagues show that disruption of a hydrophobic patch in the T cell antigen receptor on natural killer T cells alters their development, which results in the selective accumulation of adipose-tissue-specific natural killer T cells.

Joshua A Vieth
Joy Das
Derek B Sant'Angelo
Research21 Nov 2016
Nature Immunology

Volume: 18, P: 36-44
Genomics yields biological and phenotypic insights into bipolar disorder

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Kevin S. O’Connell
Maria Koromina
Dan Siskind
Research22 Jan 2025
Nature

Volume: 639, P: 968-975
Mammal responses to global changes in human activity vary by trophic group and landscape

Analysing camera-trap data of 163 mammal species before and after the onset of COVID-19 lockdowns, the authors show that responses to human activity are dependent on the degree to which the landscape is modified by humans, with carnivores being especially sensitive.

A. Cole Burton
Christopher Beirne
Roland Kays
ResearchOpen Access18 Mar 2024
Nature Ecology & Evolution

Volume: 8, P: 924-935
Harnessing microbially generated power on the seafloor

Leonard M. Tender
Clare E. Reimers
Derek R. Lovley
Research01 Jul 2002
Nature Biotechnology

Volume: 20, P: 821-825
YY1^lo NKT cells are dedicated IL-10 producers

Patrick W. Darcy
Lisa K. Denzin
Derek B. Sant’Angelo
ResearchOpen Access03 Mar 2020
Scientific Reports

Volume: 10, P: 1-15
Mapping genomic loci implicates genes and synaptic biology in schizophrenia

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

Vassily Trubetskoy
Antonio F. Pardiñas
Jim van Os
Research08 Apr 2022
Nature

Volume: 604, P: 502-508
Per and polyfluoroalkyl substances (PFAS) blood levels after contamination of a community water supply and comparison with 2013–2014 NHANES

Judith M. Graber
Cora Alexander
Clifford P. Weisel
Research27 Nov 2018
Journal of Exposure Science & Environmental Epidemiology

Volume: 29, P: 172-182
Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies

In this work, researchers engineer HIV-1 immunogens using molecular dynamics simulations to enhance vaccine designs that select for specific antibody mutations. Their approach improved the selection of mutations crucial for broadly neutralizing antibody responses, offering a promising strategy for HIV vaccine development.

Rory Henderson
Kara Anasti
Barton F. Haynes
ResearchOpen Access03 Nov 2024
Nature Communications

Volume: 15, P: 1-20
Exocyst function regulated by effector phosphorylation

How do exocytic vesicles disengage from the exocyst complex? Phosphorylation of the RalA GTPase effector Sec5, rather than RalA inactivation per se, is now shown to mediate dissociation of the Sec5–RalA complex.

Xiao-Wei Chen
Dara Leto
Alan R. Saltiel
Research24 Apr 2011
Nature Cell Biology

Volume: 13, P: 580-588
Variability in the analysis of a single neuroimaging dataset by many teams

The results obtained by seventy different teams analysing the same functional magnetic resonance imaging dataset show substantial variation, highlighting the influence of analytical choices and the importance of sharing workflows publicly and performing multiple analyses.

Rotem Botvinik-Nezer
Felix Holzmeister
Tom Schonberg
Research20 May 2020
Nature

Volume: 582, P: 84-88
3D genetic architecture of schizophrenia risk across three neuronal subtypes

Samuel K. Powell
Will Liao
Kristen J. Brennand
ResearchOpen Access28 Nov 2025
Molecular Psychiatry

P: 1-16
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations

To overcome limitations of previous genome-wide association studies of coronary artery disease, this study incorporates a cohort of individuals containing large fractions of Black and Hispanic individuals to provide a wider view of the genetic landscape of this disease.

Catherine Tcheandjieu
Xiang Zhu
Themistocles L. Assimes
Research01 Aug 2022
Nature Medicine

Volume: 28, P: 1679-1692
APOE4 genetic polymorphism results in impaired recovery in a repeated mild traumatic brain injury model and treatment with Bryostatin-1 improves outcomes

Anna O. Giarratana
Cynthia Zheng
Janet Alder
ResearchOpen Access16 Nov 2020
Scientific Reports

Volume: 10, P: 1-17
Evolution of immune genes is associated with the Black Death

Klunk and colleagues identify signatures of natural selection imposed by Yersinia pestis and demonstrate their effect on genetic diversity and susceptibility to certain diseases in the present day.

Jennifer Klunk
Tauras P. Vilgalys
Luis B. Barreiro
Research19 Oct 2022
Nature

Volume: 611, P: 312-319
Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T_reg cells and macrophages in adipose tissue

iNKT cells in adipose tissue are anti-inflammatory. Brenner and colleagues show that adipose iNKT cells have a unique transcriptional program, produce IL-2 and IL-10 and lack expression of the transcription factor PLZF.

Lydia Lynch
Xavier Michelet
Michael B Brenner
Research01 Dec 2014
Nature Immunology

Volume: 16, P: 85-95
Bone marrow-derived epithelial cells and hair follicle stem cells contribute to development of chronic cutaneous neoplasms

Bone marrow-derived epithelial cells can be recruited to sites of chronic inflammation. Here, the authors using allogenic bone marrow transplantation in a multistage murine cutaneous carcinogenesis model show that bone marrow-derived epithelial cells and hair follicle stem cells are recruited to cutaneous neoplasms during tumor promotion of carcinogen-exposed skin and bone marrow.

Heuijoon Park
Sonali Lad
Rebecca J. Morris
ResearchOpen Access13 Dec 2018
Nature Communications

Volume: 9, P: 1-15
A PAX1 enhancer locus is associated with susceptibility to idiopathic scoliosis in females

Girls are tenfold more likely than boys to require surgical treatment for idiopathic scoliosis, a common paediatric skeletal disorder. Here, Sharma et al. identify the first sexually dimorphic idiopathic scoliosis risk locus, and demonstrate that it may play a role in the regulation of spinal cells.

Swarkar Sharma
Douglas Londono
Carol A. Wise
ResearchOpen Access18 Mar 2015
Nature Communications

Volume: 6, P: 1-10
RNAi promotes heterochromatic silencing through replication-coupled release of RNA Pol II

Mikel Zaratiegui
Stephane E. Castel
Robert A. Martienssen
Research16 Oct 2011
Nature

Volume: 479, P: 135-138
The role of the tumor suppressor p53 in spermatogenesis

Tim L Beumer
Hermien L Roepers-Gajadien
Dirk G de Rooij
Research03 Aug 1998
Cell Death & Differentiation

Volume: 5, P: 669-677
Disruption of P2RY5, an orphan G protein–coupled receptor, underlies autosomal recessive woolly hair

Yutaka Shimomura
Muhammad Wajid
Angela M Christiano
Research24 Feb 2008
Nature Genetics

Volume: 40, P: 335-339
Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis

Shiro Ikegawa and colleagues report a genome-wide association study for adolescent idiopathic scoliosis (AIS). They identify one locus associated with AIS on chromosome 6q24.1 in Japanese individuals, which was also replicated in individuals of Han Chinese and European ancestry.

Ikuyo Kou
Yohei Takahashi
Shiro Ikegawa
Research12 May 2013
Nature Genetics

Volume: 45, P: 676-679
Anomalous orbital structure in a spinel–perovskite interface

Yanwei Cao
Xiaoran Liu
Jak Chakhalian
ResearchOpen Access12 Aug 2016
npj Quantum Materials

Volume: 1, P: 1-6
Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance

Ashlee Earl and colleagues analyze whole-genome sequences from 5,310 Mycobacterium tuberculosis isolates from five continents. They find that resistance to isoniazid arises before rifampicin resistance across all of the lineages, geographical regions and time periods.

Abigail L Manson
Keira A Cohen
Ashlee M Earl
Research16 Jan 2017
Nature Genetics

Volume: 49, P: 395-402
Reply to: Insufficient evidence for natural selection associated with the Black Death

Tauras P. Vilgalys
Jennifer Klunk
Luis B. Barreiro
Research19 Feb 2025
Nature

Volume: 638, P: E23-E29
Intertwined superfluid and density wave order in two-dimensional ⁴He

A detailed analysis of low-temperature torsional oscillation measurements on two-dimensional ⁴He reveals evidence for intertwined superfluid and density wave order in this system.

Ján Nyéki
Anastasia Phillis
John Saunders
Research06 Feb 2017
Nature Physics

Volume: 13, P: 455-459
Integrative scATAC-seq and scRNA-seq analyses map thymic iNKT cell development and identify Cbfβ for its commitment

Jie Wang
Indra Adrianto
Qing-Sheng Mi
ResearchOpen Access20 Jun 2023
Cell Discovery

Volume: 9, P: 1-20
Perovskite nickelates as electric-field sensors in salt water

Application of an electric field changes the transport and optical properties of samarium nickelate submerged in water, making it a suitable passive sensor of weak electric fields in salt water.

Zhen Zhang
Derek Schwanz
Shriram Ramanathan
Research18 Dec 2017
Nature

Volume: 553, P: 68-72
Zbtb16 (PLZF) is stably suppressed and not inducible in non-innate T cells via T cell receptor-mediated signaling

Sai Zhang
Amale Laouar
Derek B. Sant’Angelo
ResearchOpen Access16 Jul 2015
Scientific Reports

Volume: 5, P: 1-13
The common marmoset genome provides insight into primate biology and evolution

Kim Worley and colleagues report the whole-genome sequence of the common marmoset, Callithrix jacchus, the first New World monkey to be sequenced.

Kim C Worley
Wesley C Warren
Richard K Wilson
ResearchOpen Access20 Jul 2014
Nature Genetics

Volume: 46, P: 850-857
Identification of common variants associated with human hippocampal and intracranial volumes

Paul Thompson and colleagues report a genome-wide association study for hippocampal, intracranial and total brain volume. They identify a locus at 12q24 associated with hippocampal volume and a locus at 12q14 associated with intracranial volume.

Jason L Stein
Sarah E Medland
Paul M Thompson
Research15 Apr 2012
Nature Genetics

Volume: 44, P: 552-561
Leukotoxin (LtxA/Leukothera) induces ATP expulsion via pannexin-1 channels and subsequent cell death in malignant lymphocytes

Derek J. Prince
Deendayal Patel
Scott C. Kachlany
ResearchOpen Access10 Sept 2021
Scientific Reports

Volume: 11, P: 1-14
Relationship of Indoor, Outdoor and Personal Air (RIOPA) study: study design, methods and quality assurance/control results

Clifford P Weisel
Junfeng (Jim) Zhang
Derek Shendell
Research23 Jun 2004
Journal of Exposure Science & Environmental Epidemiology

Volume: 15, P: 123-137
Air concentrations of VOCs in portable and traditional classrooms: Results of a pilot study in Los Angeles County

Derek G Shendell
Arthur M Winer
Steven D Colome
Research02 Jan 2004
Journal of Exposure Science & Environmental Epidemiology

Volume: 14, P: 44-59
Global patterns and predictors of marine biodiversity across taxa

Using large-scale data sets, these authors present a new assessment of global marine species diversity and its correlation with environmental and spatial parameters.

Derek P. Tittensor
Camilo Mora
Boris Worm
Research28 Jul 2010
Nature

Volume: 466, P: 1098-1101
AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Abraham Heifets
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-16
Chinese scientists and US leadership in the life sciences

Steven H. Holtzman
Ron Cohen
Shuguang Zhang
Correspondence03 Oct 2019
Nature Biotechnology

Volume: 37, P: 1261-1263
The differentiation of ROR-γt expressing iNKT17 cells is orchestrated by Runx1

Puspa Thapa
Bryce Manso
Virginia Smith Shapiro
ResearchOpen Access01 Aug 2017
Scientific Reports

Volume: 7, P: 1-13
1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans

Ida E. Sønderby
Dennis van der Meer
Marianne B. M. van den Bree
ResearchOpen Access22 Mar 2021
Translational Psychiatry

Volume: 11, P: 1-16
Impaired mitochondrial function in psychiatric disorders

A growing body of evidence suggests that many psychiatric illnesses are associated with impaired mitochondrial function. Manji and colleagues review evidence from studies in animal models and humans and discuss strategies for therapeutics aimed at enhancing mitochondrial function in patients with psychiatric disorders.

Husseini Manji
Tadafumi Kato
Guang Chen
Reviews18 Apr 2012
Nature Reviews Neuroscience

Volume: 13, P: 293-307
Influence of ambient (outdoor) sources on residential indoor and personal PM_2.5 concentrations: Analyses of RIOPA data

Qing Yu Meng
Barbara J Turpin
Silvia Maberti
Research12 May 2004
Journal of Exposure Science & Environmental Epidemiology

Volume: 15, P: 17-28
Fine organic particulate matter dominates indoor-generated PM_2.5 in RIOPA homes

Andrea Polidori
Barbara Turpin
Silvia Maberti
Research15 Mar 2006
Journal of Exposure Science & Environmental Epidemiology

Volume: 16, P: 321-331
Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Ellie Giles
Amendments and CorrectionsOpen Access16 Sept 2024
Scientific Reports

Volume: 14, P: 1-2

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