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Showing 1–9 of 9 results
Advanced filters: Author: Derek P. Narendra Clear advanced filters

  • Tacrolimus is a critical immunosuppressant for liver transplant recipients, but its dosing is challenging due to individual variability. Here, the authors show that a phenotypic personalized medicine approach improves tacrolimus dosing precision, reducing large deviations from target levels and shortening hospital stays in a Phase 2 randomized trial.

    • Jeffrey Khong
    • Megan Lee
    • Ali Zarrinpar
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10

  • Narendra and Youle review the current understanding of the role of PINK1–Parkin in the quality control of mitophagy, highlighting the underlying mechanisms and physiological relevance of the pathway, as well as its role in neuroprotection.

    • Derek P. Narendra
    • Richard J. Youle
    Reviews
    Nature Cell Biology
    Volume: 26, P: 1639-1651

  • Mitophagy is the selective elimination of mitochondria through autophagy. Recent studies have uncovered the molecular mechanisms mediating mitophagy in yeast and mammalian cells and have revealed that the dysregulation of one of these mechanisms — the PINK1–parkin-mediated signalling pathway — may contribute to Parkinson's disease.

    • Richard J. Youle
    • Derek P. Narendra
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 9-14

  • Studies of rare hereditary disorders are intended to find treatments, but they can also bring other discoveries. One such study links the dysfunction of a protein to that of the cell's energy producers, the mitochondria.

    • Derek P. Narendra
    • Richard J. Youle
    News & Views
    Nature
    Volume: 483, P: 418-419

  • There is currently no disease-modifying treatment for Parkinson’s disease, a common neurodegenerative disorder. Here, the authors use genetic variation associated with gene and protein expression to find putative drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome.

    • Catherine S. Storm
    • Demis A. Kia
    • Nicholas W. Wood
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14