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Showing 1–17 of 17 results
Advanced filters: Author: Derrick Brittain Clear advanced filters

  • FlyWire presents a neuronal wiring diagram of the whole fly brain with annotations for cell types, classes, nerves, hemilineages and predicted neurotransmitters, with data products and an open ecosystem to facilitate exploration and browsing.

    • Sven Dorkenwald
    • Arie Matsliah
    • Meet Zandawala
    ResearchOpen Access
    Nature
    Volume: 634, P: 124-138

  • Electron microscopy (EM) is the gold standard for biological ultrastructure but acquisition speed is slow, making it unsuitable for large volumes. Here the authors present a parallel imaging pipeline for continuous autonomous imaging with six transmission EMs to image 1 mm3 of mouse cortex in less than 6 months.

    • Wenjing Yin
    • Derrick Brittain
    • Nuno Macarico da Costa
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • The Connectome Annotation Versioning Engine (CAVE) is a platform for proofreading, annotating and analyzing datasets reaching the petascale. Currently, CAVE is used for electron microscopy datasets, but it can potentially be used for other large-scale datasets.

    • Sven Dorkenwald
    • Casey M. Schneider-Mizell
    • Forrest Collman
    ResearchOpen Access
    Nature Methods
    Volume: 22, P: 1112-1120

  • Neural Decomposition (NEURD) is a software package that decomposes neuronal data from high-resolution electron microscopy volumes into feature-rich graph representations to facilitate analysis for neuroscience research.

    • Brendan Celii
    • Stelios Papadopoulos
    • Jacob Reimer
    ResearchOpen Access
    Nature
    Volume: 640, P: 487-496

  • Excitatory neurons in the neocortex exhibit considerable morphological diversity, yet their organizational principles remain a subject of ongoing research. Here, the authors use unsupervised learning to show that most excitatory neuron morphologies in the mouse visual cortex form a continuum, with notable exceptions in deeper layers.

    • Marissa A. Weis
    • Stelios Papadopoulos
    • Alexander S. Ecker
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Using volumetric electron microscopy, the authors map and analyze the structure of cortical inhibition with synaptic resolution across a column of visual cortex.

    • Casey M. Schneider-Mizell
    • Agnes L. Bodor
    • Nuno Maçarico da Costa
    ResearchOpen Access
    Nature
    Volume: 640, P: 448-458

  • The MICrONS mouse visual cortex dataset shows that neurons with similar response properties preferentially connect, a pattern that emerges within and across brain areas and layers, and independently emerges in artificial neural networks where these ‘like-to-like’ connections prove important for task performance.

    • Zhuokun Ding
    • Paul G. Fahey
    • Andreas S. Tolias
    ResearchOpen Access
    Nature
    Volume: 640, P: 459-469

  • FlyWire is an online community and a platform for proofreading electron microscopy-based connectome data of the Drosophila brain.

    • Sven Dorkenwald
    • Claire E. McKellar
    • H. Sebastian Seung
    Research
    Nature Methods
    Volume: 19, P: 119-128

  • We use connectomics to compare the wiring logic of premotor circuits controlling the Drosophila leg and wing, finding that both premotor networks cluster into modules that link motor neurons innervating muscles with related functions.

    • Ellen Lesser
    • Anthony W. Azevedo
    • John C. Tuthill
    Research
    Nature
    Volume: 631, P: 369-377

  • Dense calcium imaging combined with co-registered high-resolution electron microscopy reconstruction of the brain of the same mouse provide a functional connectomics map of tens of thousands of neurons of a region of the primary cortex and higher visual areas.

    • J. Alexander Bae
    • Mahaly Baptiste
    • Chi Zhang
    ResearchOpen Access
    Nature
    Volume: 640, P: 435-447

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477