Nature Search

Perceived life expectancy and life purpose mediate relation between discrimination and suicide attempts in LGBTQ+ youth

In this study, Hobaica and colleagues investigate how perceived life expectancy and life purpose mediate the relationship between gender- and sexual orientation-based discrimination and suicide risk in a large US sample of LGBTQ+ youth.

Steven Hobaica
Derrick D. Matthews
Ronita Nath
Research14 Aug 2025
Nature Mental Health

Volume: 3, P: 1070-1077
Ligand-promoted protein folding by biased kinetic partitioning

Pharmacological chaperones improve folding of destabilized Escherichia coli dihydrofolate reductase (DHFR) and human disease-linked α-galactosidase A (α-GAL) by biasing the kinetic partitioning between folding, aggregation, and degradation. Chaperoning spares DHFR from aggregation and α-GAL from degradation.

Karan S Hingorani
Matthew C Metcalf
Lila M Gierasch
Research20 Feb 2017
Nature Chemical Biology

Volume: 13, P: 369-371
Effect of Delta variant on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK

A large, community-based study in the United Kingdom indicates that the effectiveness of BNT162b2 and ChAdOx1 vaccines against SARS-CoV-2 infections with symptoms or high viral burden is reduced with the Delta variant compared to the Alpha variant.

Koen B. Pouwels
Emma Pritchard
A. Sarah Walker
ResearchOpen Access14 Oct 2021
Nature Medicine

Volume: 27, P: 2127-2135
Impact of vaccination on new SARS-CoV-2 infections in the United Kingdom

Results from the Office of National Statistics COVID-19 Infection Survey in the United Kingdom demonstrate that the ChAdOx1 nCoV-19 and BNT162b2 vaccines reduce the incidence of new SARS-CoV-2 infections by up to 65% with a single dose and up to 80% after two doses, with no significant differences in efficacy observed between the two vaccines.

Emma Pritchard
Philippa C. Matthews
Koen B. Pouwels
ResearchOpen Access09 Jun 2021
Nature Medicine

Volume: 27, P: 1370-1378
Improving the representativeness of UK’s national COVID-19 Infection Survey through spatio-temporal regression and post-stratification

Estimates of infection rates from the UK COVID-19 Infection Survey may have been biased by the characteristics of people who chose to take part. Here, the authors show that the survey population had unusually high vaccination rates and adjust infection estimates taking this into account.

Koen B. Pouwels
David W. Eyre
Chris Cunningham
ResearchOpen Access24 Jun 2024
Nature Communications

Volume: 15, P: 1-12
Antibody responses to SARS-CoV-2 vaccines in 45,965 adults from the general population of the United Kingdom

Longitudinal tracing of antibody responses to the ChAdOx1 and the BNT162b2 COVID-19 vaccines in 45,965 adults from the United Kingdom give indications for vaccine prioritization.

Jia Wei
Nicole Stoesser
Jessica Lee
ResearchOpen Access21 Jul 2021
Nature Microbiology

Volume: 6, P: 1140-1149
SARS-CoV-2 antibody trajectories after a single COVID-19 vaccination with and without prior infection

The impact of prior infection on the immune response to COVID-19 vaccination has not been fully characterised. Here, the authors use data from ~100,000 adults in the UK and find that a single vaccine dose in those with prior infection produces a comparable or stronger response to two doses in those without infection.

Jia Wei
Philippa C. Matthews
Chris Cunningham
ResearchOpen Access29 Jun 2022
Nature Communications

Volume: 13, P: 1-9
A haemagglutination test for rapid detection of antibodies to SARS-CoV-2

Serological detection of antibodies against SARS-CoV-2 can help establish rates of seroconversion. Here the authors develop a red cell agglutination test to detect antibodies against the receptor binding domain for distribution free of charge to qualified research groups.

Alain Townsend
Pramila Rijal
Etienne Joly
ResearchOpen Access29 Mar 2021
Nature Communications

Volume: 12, P: 1-12
Anti-spike antibody response to natural SARS-CoV-2 infection in the general population

Most people who are infected with SARS-CoV-2 seroconvert within a few weeks, but the determinants and duration of the antibody response are not known. Here, the authors characterise these features of the immune response using data from a large representative community sample of the UK population.

Jia Wei
Philippa C. Matthews
Chris Cunningham
ResearchOpen Access29 Oct 2021
Nature Communications

Volume: 12, P: 1-12
Risk of SARS-CoV-2 reinfection during multiple Omicron variant waves in the UK general population

The factors influencing risk of reinfection with SARS-CoV-2 are poorly understood. Here, the authors use data from the UK COVID-19 Infection Survey, a community based longitudinal study, to assess characteristics of ~45,000 reinfections compared to initial infections.

Jia Wei
Nicole Stoesser
Chris Cunningham
ResearchOpen Access02 Feb 2024
Nature Communications

Volume: 15, P: 1-14
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Antibody responses and correlates of protection in the general population after two doses of the ChAdOx1 or BNT162b2 vaccines

A large study in the United Kingdom shows that virus-specific antibody levels associated with at least 67% protection against SARS-CoV-2 Delta variant infection last longer after two doses of BNT162b2 vaccine than after two doses of ChAdOx1 vaccine in previously uninfected individuals.

Jia Wei
Koen B. Pouwels
Chris Cunningham
ResearchOpen Access14 Feb 2022
Nature Medicine

Volume: 28, P: 1072-1082
Protection against SARS-CoV-2 Omicron BA.4/5 variant following booster vaccination or breakthrough infection in the UK

The duration and strength of protection against SARS-CoV-2 infection resulting from a booster vaccine dose or breakthrough infection are not well understood. This study uses data from the UK COVID-19 Infection Survey to investigate correlates of protection against Omicron BA.4/5 infection and assess antibody responses to booster vaccination and breakthrough infections.

Jia Wei
Philippa C. Matthews
Chris Cunningham
ResearchOpen Access16 May 2023
Nature Communications

Volume: 14, P: 1-15
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Identification of undetected SARS-CoV-2 infections by clustering of Nucleocapsid antibody trajectories

Many SARS-CoV-2 infections may go undetected through conventional PCR or lateral flow tests. Here, the authors analyse the utility of analysing longitudinal nucleocapsid antibody trajectories to improve identification of prior SARS-CoV-2 infections using surveillance data from the UK.

Leslie R. Zwerwer
Tim E. A. Peto
Chris Cunningham
ResearchOpen Access14 May 2025
Nature Communications

Volume: 16, P: 1-13
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

In this study, Aggarwal and colleagues perform prospective sequencing of SARS-CoV-2 isolates derived from asymptomatic student screening and symptomatic testing of students and staff at the University of Cambridge. They identify important factors that contributed to within university transmission and onward spread into the wider community.

Dinesh Aggarwal
Ben Warne
Ian G. Goodfellow
ResearchOpen Access08 Feb 2022
Nature Communications

Volume: 13, P: 1-16
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Chemoresistance of TP53 mutant acute myeloid leukemia requires the mevalonate byproduct, geranylgeranyl pyrophosphate, for induction of an adaptive stress response

Sarah J. Skuli
A’ishah Bakayoko
Martin Carroll
ResearchOpen Access09 Jul 2025
Leukemia

Volume: 39, P: 2087-2098
In-silico design of a multi-epitope vaccine candidate against onchocerciasis and related filarial diseases

Robert Adamu Shey
Stephen Mbigha Ghogomu
Jacob Souopgui
ResearchOpen Access13 Mar 2019
Scientific Reports

Volume: 9, P: 1-18
Viral detection and identification in 20 min by rapid single-particle fluorescence in-situ hybridization of viral RNA

Christof Hepp
Nicolas Shiaelis
Achillefs N. Kapanidis
ResearchOpen Access01 Oct 2021
Scientific Reports

Volume: 11, P: 1-12
Maternal prenatal psychological distress and vitamin intake with children’s neurocognitive development

Derrick Ssewanyana
Julia A. Knight
Rayjean J. Hung
Research14 Mar 2022
Pediatric Research

Volume: 92, P: 1450-1457

Search

Perceived life expectancy and life purpose mediate relation between discrimination and suicide attempts in LGBTQ+ youth

Ligand-promoted protein folding by biased kinetic partitioning

Effect of Delta variant on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK

Impact of vaccination on new SARS-CoV-2 infections in the United Kingdom

Improving the representativeness of UK’s national COVID-19 Infection Survey through spatio-temporal regression and post-stratification

Antibody responses to SARS-CoV-2 vaccines in 45,965 adults from the general population of the United Kingdom

SARS-CoV-2 antibody trajectories after a single COVID-19 vaccination with and without prior infection

A haemagglutination test for rapid detection of antibodies to SARS-CoV-2

Anti-spike antibody response to natural SARS-CoV-2 infection in the general population

Risk of SARS-CoV-2 reinfection during multiple Omicron variant waves in the UK general population

Mapping the human genetic architecture of COVID-19

Antibody responses and correlates of protection in the general population after two doses of the ChAdOx1 or BNT162b2 vaccines

Protection against SARS-CoV-2 Omicron BA.4/5 variant following booster vaccination or breakthrough infection in the UK

Whole-genome sequencing reveals host factors underlying critical COVID-19

Identification of undetected SARS-CoV-2 infections by clustering of Nucleocapsid antibody trajectories

Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

A second update on mapping the human genetic architecture of COVID-19

Chemoresistance of TP53 mutant acute myeloid leukemia requires the mevalonate byproduct, geranylgeranyl pyrophosphate, for induction of an adaptive stress response

In-silico design of a multi-epitope vaccine candidate against onchocerciasis and related filarial diseases

Viral detection and identification in 20 min by rapid single-particle fluorescence in-situ hybridization of viral RNA

Maternal prenatal psychological distress and vitamin intake with children’s neurocognitive development

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