Encoded libraries of synthetic macrocycles generated by ring-closing metathesis (RCM) hold significant potential to address conventionally undruggable targets, but the application of RCM to oligonucleotide-conjugated systems has been restricted. Here, authors report the synthesis of nucleic acid-tagged macrocycles via RCM in neat water, using an anionic, water-soluble ruthenium catalyst.
- Chun Zhang
- Christian O. Blanco
- Andreas Brunschweiger
