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Mutant APC reshapes Wnt signaling plasma membrane nanodomains by altering cholesterol levels via oncogenic β-catenin

Dynamic proteolipid nanoassemblies at the plasma membrane of colonocytes serve as Wnt signaling hubs. Here, the authors find a role for mutant APC in colorectal cancer in the dysregulation of plasma membrane sterol homeostasis.

Alfredo Erazo-Oliveras
Mónica Muñoz-Vega
Robert S. Chapkin
ResearchOpen Access19 Jul 2023
Nature Communications

Volume: 14, P: 1-28

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Mutant APC reshapes Wnt signaling plasma membrane nanodomains by altering cholesterol levels via oncogenic β-catenin

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