The wildlife reservoir Peromyscus leucopus – the white-footed mouse - is a primary driver of Lyme disease. Here, authors engineer mice to express a neutralizing anti-OspA antibody, blocking Borrelia infection in vivo and demonstrating heritable immunity as a viable intervention to break the tick-mouse transmission cycle.
- Joanna Buchthal
- Emma J. Chory
- Kevin M. Esvelt
