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Virus glycoprotein nanodisc platform for vaccine analytics

Many viral vaccine antigen candidates are transmembrane glycoproteins, and their development requires methods which allow their biophysical characterization. Here authors present an optimized nanodisc assembly platform which provides reproducible, scalable, and accurate replication of the vaccine candidates for detailed analysis.

Kimmo Rantalainen
Alessia Liguori
William R. Schief
ResearchOpen Access10 Feb 2026
Nature Communications

P: 1-17
Publisher Correction: Recent progress in broadly neutralizing antibodies to HIV

Devin Sok
Dennis R. Burton
Amendments and Corrections01 Feb 2019
Nature Immunology

Volume: 20, P: 374
Vaccination induces broadly neutralizing antibody precursors to HIV gp41

Schief and colleagues show that germline-targeting epitope scaffolds can elicit responses from rare broadly neutralizing antibody precursor B cells with predefined binding specificities and genetic features.

Torben Schiffner
Ivy Phung
William R. Schief
ResearchOpen Access30 May 2024
Nature Immunology

Volume: 25, P: 1073-1082
Identification of IOMA-class neutralizing antibodies targeting the CD4-binding site on the HIV-1 envelope glycoprotein

HIV-1 vaccine design aims to induce broadly neutralizing antibodies such as IOMA, the only described antibody in its class. Here, the authors present the isolation, characterisation and structure of three additional antibodies within the IOMA class

Jelle van Schooten
Elinaz Farokhi
Marit J. van Gils
ResearchOpen Access03 Aug 2022
Nature Communications

Volume: 13, P: 1-15
Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria

Antibody based biologics are a rapidly growing class of therapeutics with interest to enhance their performance, distribution, longevity and effectivity. Here, authors report the engineering of human IgG Fc to enhance plasma half-life, mucosal distribution and killing of cancer cells and bacteria.

Stian Foss
Siri A. Sakya
Jan Terje Andersen
ResearchOpen Access07 Mar 2024
Nature Communications

Volume: 15, P: 1-16
Author Correction: Vaccination induces broadly neutralizing antibody precursors to HIV gp41

Torben Schiffner
Ivy Phung
William R. Schief
Amendments and CorrectionsOpen Access14 Jun 2024
Nature Immunology

Volume: 25, P: 1307
Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles

The development of native-like envelope trimers has been a major focus in the efforts to produce HIV vaccines. Here the authors demonstrate the production and characterization of virus-like nanoparticles displaying trimeric HIV-1 antigens with the potential to elicit broadly neutralizing antibodies.

Linling He
Natalia de Val
Jiang Zhu
ResearchOpen Access28 Jun 2016
Nature Communications

Volume: 7, P: 1-15
Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability

A major goal of HIV-1 vaccine development is to produce antigens that can induce broadly neutralizing antibodies. Here the authors examine the underlying causes of HIV-1 envelope metastability and design uncleaved, prefusion-optimized gp140 trimers with potential for use as HIV-1 vaccine antigens.

Leopold Kong
Linling He
Jiang Zhu
ResearchOpen Access28 Jun 2016
Nature Communications

Volume: 7, P: 1-15
Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus

SIVmac239 infection of macaques is a favored model of human HIV infection, but antibody-mediated protection for SIVmac239 is insufficiently understood. Here, Zhao and Berndsen et al isolated nAbs and confirmed protection against SIVmac239 infection in passive transfer studies in macaques. The nAb was used to provide the first high-resolution structure of a rhesus SIV trimer by CryoEM. Analysis of the glycosylation pattern of this SIV trimer suggests a denser glycan shield on Env for rhesus SIV compared to chimpanzee SIV or HIV-1, which partially explains the poor nAb response of rhesus macaques to SIVmac239 infection.

Fangzhu Zhao
Zachary T. Berndsen
Devin Sok
ResearchOpen Access06 Sept 2022
Nature Communications

Volume: 13, P: 1-16
Recent progress in broadly neutralizing antibodies to HIV

Sok and Burton highlight recent developments in the discovery and application of antibodies able to neutralize diverse isolates of HIV, known as ‘broadly neutralizing antibodies’.

Devin Sok
Dennis R. Burton
Reviews17 Oct 2018
Nature Immunology

Volume: 19, P: 1179-1188
Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows

Immunization of cows with a recombinant HIV envelope protein leads to the rapid development of potent, broadly neutralizing antibodies against HIV.

Devin Sok
Khoa M. Le
Dennis R. Burton
Research20 Jul 2017
Nature

Volume: 548, P: 108-111
An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability

The cryo-EM structure of an HIV-1 broadly neutralizing antibody from an elite neutralizer reveals the fusion peptide of the envelope glycoprotein (Env) as a site of vulnerability that may be explored by future therapies.

Marit J. van Gils
Tom L. G. M. van den Kerkhof
Rogier W. Sanders
Research14 Nov 2016
Nature Microbiology

Volume: 2, P: 1-10
Global site-specific N-glycosylation analysis of HIV envelope glycoprotein

The analysis of site-specific glycosylation of HIV Envelope glycoprotein (Env) is challenging as it contains 25–30 glycosylation sites with multiple glycan forms at each site. Here the authors present a generally applicable mass spectrometry-based method for site-specific analysis of protein glycosylation that they apply to the analysis of the HIV-1 Env.

Liwei Cao
Jolene K. Diedrich
James C. Paulson
ResearchOpen Access28 Mar 2017
Nature Communications

Volume: 8, P: 1-13
Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer

HIV envelope (Env) is a potential vaccine antigen and its N-glycans are part of the epitope of broadly neutralizing antibodies. Here, the authors show that glycosylation of Env from infectious virus closely matches Env from recombinant membrane-bound trimers, while it differs significantly from recombinant soluble, cleaved Env trimers.

Liwei Cao
Matthias Pauthner
James C. Paulson
ResearchOpen Access12 Sept 2018
Nature Communications

Volume: 9, P: 1-14
Toward a more accurate view of human B-cell repertoire by next-generation sequencing, unbiased repertoire capture and single-molecule barcoding

Linling He
Devin Sok
Jiang Zhu
ResearchOpen Access27 Oct 2014
Scientific Reports

Volume: 4, P: 1-12

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