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Showing 1–3 of 3 results
Advanced filters: Author: Devin W. Kolmetzky Clear advanced filters

  • Myofibroblast differentiation contributes to extracellular matrix remodeling and fibrosis. Here, the authors report that alterations in mitochondrial calcium uptake is essential for metabolic reprogramming and epigenetic signaling for activation of the myofibroblast gene program.

    • Alyssa A. Lombardi
    • Andrew A. Gibb
    • John W. Elrod
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • Dysregulation of intracellular calcium is reported in Alzheimer’s disease. Here the authors show that loss of the mitochondrial Na+ /Ca2+ exchanger, NCLX – primary route of mitochondrial calcium efflux, precedes neuronal pathology in experimental models and contributes to Alzheimer’s disease progression.

    • Pooja Jadiya
    • Devin W. Kolmetzky
    • John W. Elrod
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Conditional deletion of the mitochondrial Na+/Ca2+ exchanger NCLX in adult mouse hearts causes sudden death due to mitochondrial calcium overload, whereas its overexpression limits cell death elicited by ischaemia reperfusion injury and heart failure.

    • Timothy S. Luongo
    • Jonathan P. Lambert
    • John W. Elrod
    Research
    Nature
    Volume: 545, P: 93-97