Feske and colleagues show how STIM- and ORAI-dependent calcium activation of NFAT plus IFN–STAT1 signaling activates T-bet expression independently of IL-12 stimulation. This NFAT–STAT1 activation pathway is required for TH1 cell differentiation and protection against viral infections when IL-12 is missing.
- Li Zhong
- Yin-Hu Wang
- Stefan Feske
