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Author Correction: Systematic profiling of conditional pathway activation identifies context-dependent synthetic lethalities

Liang Chang
Nancy Y. Jung
William R. Sellers
Amendments and Corrections23 Feb 2024
Nature Genetics

Volume: 56, P: 553
Comparative optimization of combinatorial CRISPR screens

Combinatorial CRISPR screens can be utilized to identify genetic interactions and functional redundancies of multiple genes. Here, the authors benchmark ten digenic CRISPR technologies and identify novel Cas9 tracrRNA combinations that show superior performance.

Ruitong Li
Olaf Klingbeil
William R. Sellers
ResearchOpen Access05 May 2022
Nature Communications

Volume: 13, P: 1-10
Systematic profiling of conditional pathway activation identifies context-dependent synthetic lethalities

Gain-of-function perturbation screens across 488 barcoded cell lines identify context-specific activation lethalities. The authors show that cells with MAPK, PI3K and WNT pathway activation are vulnerable to mutations that lead to further activation, suggesting a new strategy for treating tumors driven by these oncogenic pathways.

Liang Chang
Nancy Y. Jung
William R. Sellers
Research25 Sept 2023
Nature Genetics

Volume: 55, P: 1709-1720

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