The transition of α-synuclein from biomolecular condensates to amyloid fibrils is a key process in neurodegeneration, yet the mechanisms underlying this transition remain unclear. Here, the authors use microscopy-based quantitative imaging to show that the early N-terminus decreases surface wettability and delays maturation, implicating condensate interface interactions in toxic aggregate formation.
- Rebecca J. Thrush
- Devkee M. Vadukul
- Francesco A. Aprile
