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Showing 1–5 of 5 results
Advanced filters: Author: Dhanendra Tomar Clear advanced filters

  • Although some fungal mitochondria lack the calcium uniporter, many intriguingly encode homologs of the uniporter assembly factor MCUR1. Here, the authors show that in budding yeast, the MCUR1 homologs Put6 and Put7 regulate mitochondrial proline metabolism, a function also conserved in human MCUR1.

    • Mohammad Zulkifli
    • John K. Neff
    • Vishal M. Gohil
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Myofibroblast differentiation contributes to extracellular matrix remodeling and fibrosis. Here, the authors report that alterations in mitochondrial calcium uptake is essential for metabolic reprogramming and epigenetic signaling for activation of the myofibroblast gene program.

    • Alyssa A. Lombardi
    • Andrew A. Gibb
    • John W. Elrod
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • Dysregulation of intracellular calcium is reported in Alzheimer’s disease. Here the authors show that loss of the mitochondrial Na+ /Ca2+ exchanger, NCLX – primary route of mitochondrial calcium efflux, precedes neuronal pathology in experimental models and contributes to Alzheimer’s disease progression.

    • Pooja Jadiya
    • Devin W. Kolmetzky
    • John W. Elrod
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Genetic ablation of Mitochondrial Ca2+ uptake protein 1 (MICU1) in mouse induces higher rates of perinatal lethality. Here the authors show that MICU1 expression is regulated by hypoxia in a FOXD1-dependent manner, establishing a cyclic switch between glycolytic and oxidative metabolism during development.

    • Santhanam Shanmughapriya
    • Dhanendra Tomar
    • Muniswamy Madesh
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12