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Retrieval-specific endocytosis of GluA2-AMPARs underlies adaptive reconsolidation of contextual fear

The authors show that retrieval of fear memory modifies the membrane expression of GluA2-containing AMPA receptors and synaptic strength in the dorsal hippocampus. This synaptic plasticity exerts an inhibitory constraint on memory strengthening and underlies the loss of fear response by reinterpretation of memory content during adaptive reconsolidation.

Priyanka Rao-Ruiz
Diana C Rotaru
Sabine Spijker
Research11 Sept 2011
Nature Neuroscience

Volume: 14, P: 1302-1308
Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity

Auxiliary AMPA receptor subunits can affect gating and surface mobility. Here the authors show that Shisa6 traps AMPA receptors at postsynaptic sites via PSD-95, and keeps them in an activated state in the presence of glutamate, preventing full desensitization and consequently synaptic depression.

Remco V. Klaassen
Jasper Stroeder
August B. Smit
ResearchOpen Access02 Mar 2016
Nature Communications

Volume: 7, P: 1-12
Loss of nuclear UBE3A causes electrophysiological and behavioral deficits in mice and is associated with Angelman syndrome

This paper elucidates the mechanism regulating the subcellular localization of UBE3A and demonstrates that abrogation of UBE3A nuclear localization leads to electrophysiological and behavioral impairments in mice and to Angelman syndrome in humans.

Rossella Avagliano Trezza
Monica Sonzogni
Ype Elgersma
Research24 Jun 2019
Nature Neuroscience

Volume: 22, P: 1235-1247
From bench to bedside: The mGluR5 system in people with and without Autism Spectrum Disorder and animal model systems

Cornelia Carey
Nisha Singh
Grainne McAlonan
ResearchOpen Access20 Sept 2022
Translational Psychiatry

Volume: 12, P: 1-10

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Retrieval-specific endocytosis of GluA2-AMPARs underlies adaptive reconsolidation of contextual fear

Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity

Loss of nuclear UBE3A causes electrophysiological and behavioral deficits in mice and is associated with Angelman syndrome

From bench to bedside: The mGluR5 system in people with and without Autism Spectrum Disorder and animal model systems

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