VopL is a bacterial actin nucleation factor that induces actin stress fibers when injected by bacteria into eukaryotic host cells. Biochemical and structural analyses of VopL-mediated actin nucleation suggest a model in which contacts between the Wiskott-Aldrich homology 2 motifs and the C-terminal domain of VopL stabilize interstrand contacts between the initial actin monomers to create a filament nucleus.
- Bingke Yu
- Hui-Chun Cheng
- Michael K Rosen