Cyclin-dependent kinase 5 phosphorylates Ape1, a regulator of base excision repair, to reduce its endonuclease activity and increase neuronal death following treatment with neurotoxins. Interestingly, increase in Ape1 phosphorylation is also observed in patients with neurodegenerative diseases.
- En Huang
- Dianbo Qu
- David S. Park
