Nature Search

Subunits βγ of heterotrimeric G protein activate β2 isoform of phospholipase C

Arieh Katz
Dianqing Wu
Melvin I. Simon
Research17 Dec 1992
Nature

Volume: 360, P: 686-689
Structural basis of the recognition of the Dishevelled DEP domain in the Wnt signaling pathway

Hing C. Wong
Junhao Mao
Jie Zheng
Research01 Dec 2000
Nature Structural Biology

Volume: 7, P: 1178-1184
Author Correction: Human HDAC6 senses valine abundancy to regulate DNA damage

Jiali Jin
Tong Meng
Ping Wang
Amendments and Corrections25 Jul 2025
Nature

Volume: 644, P: E34
Erratum: Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation

Huanjiao Jenny Zhou
Lingfeng Qin
Wang Min
Amendments and Corrections06 Dec 2016
Nature Medicine

Volume: 22, P: 1502
Human HDAC6 senses valine abundancy to regulate DNA damage

The histone deacetylase HDAC6 is a sensor of valine levels, and the abundance of valine in cells regulates DNA damage and cell homeostasis functions.

Jiali Jin
Tong Meng
Ping Wang
Research20 Nov 2024
Nature

Volume: 637, P: 215-223
LDL receptor-related protein 5 selectively transports unesterified polyunsaturated fatty acids to intracellular compartments

The mechanisms transporting fatty acids into the cell are not completely understood. Here, the authors discover a selective transporter for a specific class of lipids, and show its role in regulating neutrophil function during myocardial ischemia-reperfusion injury.

Wenwen Tang
Yi Luan
Dianqing Wu
ResearchOpen Access09 Apr 2024
Nature Communications

Volume: 15, P: 1-15
PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα₁₂

Wu and colleagues delineate an mTORC2-dependent cell migration pathway. They show that stimulation of the Gα₁₂ protein subunit induces the ARAF/ERK-mediated expression of the RFFL E3 ubiquitin ligase. RFFL, in turn, targets the inhibitory PRR5L subunit of the mTORC2 complex for ubiquitylation and degradation, enabling mTORC2 to phosphorylate PKC-δ and promote cell migration.

Xiaoqing Gan
Jiyong Wang
Dianqing Wu
Research20 May 2012
Nature Cell Biology

Volume: 14, P: 686-696
PLCβ2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1

Phospholipase C β (PLCβ) exhibits immuno-modulatory functions but its role in antiviral innate responses is unclear. Here, the authors provide evidence that PLCβ2 down regulates enterovirus-induced pro-inflammatory responses via inhibition of TAK1 activation, and suggest PLC as a potential therapeutic target.

Lin Wang
Yilong Zhou
Baoxue Ge
ResearchOpen Access14 Feb 2019
Nature Communications

Volume: 10, P: 1-13
The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8⁺ T cells

CD8 + T cells are central players in anti-tumour immunity. Here authors identify Cul5, a ubiquitin E3 ligase as an important inhibitor of CD8 + T cell anti-tumour cytotoxicity and persistence via involvement with both T cell receptor and cytokine-regulated central pathways.

Xiaofeng Liao
Wenxue Li
Dianqing Wu
ResearchOpen Access19 Jan 2024
Nature Communications

Volume: 15, P: 1-20
Regulation of PTEN by Rho small GTPases

Zhong Li
Xuemei Dong
Dianqing Wu
Research27 Mar 2005
Nature Cell Biology

Volume: 7, P: 399-404
DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation

A negative regulator of the Wnt pathway secreted by tumor cells promotes immune evasion by suppressing lymphocyte cytotoxicity.

Qian Xiao
Jibo Wu
Dianqing Wu
Research12 Feb 2018
Nature Medicine

Volume: 24, P: 262-270
Resolution of structure of PIP5K1A reveals molecular mechanism for its regulation by dimerization and dishevelled

Type I phosphatidylinositol phosphate kinase is an important component of many cellular pathways, including Wnt signalling. Here the authors report the crystal structure of the zebrafish protein along with in vitroassays that help to elucidate the regulation and function of this kinase.

Jian Hu
Qianying Yuan
Dianqing Wu
ResearchOpen Access14 Sept 2015
Nature Communications

Volume: 6, P: 1-11
Characterization of Function of Three Domains in Dishevelled-1: DEP Domain is Responsible for Membrane Translocation of Dishevelled-1

Wei Jun PAN
Shu Zhao PANG
Lin LI
Research01 Aug 2004
Cell Research

Volume: 14, P: 324-330
Cell stimulation with optically manipulated microsources

Microsources positioned with holographic optical tweezers can establish a highly localized, three-dimensional chemical gradient that allows the manipulation of polarization and migration in single cells.

Holger Kress
Jin-Gyu Park
Eric R Dufresne
Research15 Nov 2009
Nature Methods

Volume: 6, P: 905-909
Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation

Xiaofeng Li
Peng Liu
Dianqing Wu
Research31 Jul 2005
Nature Genetics

Volume: 37, P: 945-952
Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation

In a mouse model of cerebral cavernous malformation, deletion of the gene PDCD10 leads to vascular defects in the central nervous system as a result of increased UNC13-mediated exocytosis and secretion of angiopoietin-2 by endothelial cells.

Huanjiao Jenny Zhou
Lingfeng Qin
Wang Min
Research22 Aug 2016
Nature Medicine

Volume: 22, P: 1033-1042
Synaptotagmin-mediated vesicle fusion regulates cell migration

Synaptotagmins are calcium-dependent regulators of intracellular vesicle fusion. Luster and colleagues show that synaptotagmins SYT2, SYTL5 and SYT7 also regulate leukocyte chemotaxis by triggering uropod de-adhesion via the fusion of lysosomes with plasma membranes.

Richard A Colvin
Terry K Means
Andrew D Luster
Research16 May 2010
Nature Immunology

Volume: 11, P: 495-502
VCAM-1⁺ macrophages guide the homing of HSPCs to a vascular niche

In zebrafish embryogenesis, nascent haematopoietic stem and progenitor cells (HSPCs), homing to a vascular niche for retention, are ushered by patrolling and guiding macrophages through integrin-mediated cell-cell recognition.

Dantong Li
Wenzhi Xue
Weijun Pan
Research19 Nov 2018
Nature

Volume: 564, P: 119-124
In vivo self-assembled small RNAs as a new generation of RNAi therapeutics

Zheng Fu
Xiang Zhang
Xi Chen
ResearchOpen Access29 Mar 2021
Cell Research

Volume: 31, P: 631-648
Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition

Wencao Zhao
Le Cao
Weijun Pan
ResearchOpen Access09 Sept 2019
Cell Research

Volume: 29, P: 895-910
A genome-wide loss-of-function screening method for minimizing false-negatives caused by functional redundancy

Li Mao
Chenglin Liu
Lin Li
Correspondence26 Aug 2016
Cell Research

Volume: 26, P: 1067-1070
Integrin αEβ7⁺ T cells direct intestinal stem cell fate decisions via adhesion signaling

Shiyang Chen
Yajuan Zheng
Jianfeng Chen
Research13 Sept 2021
Cell Research

Volume: 31, P: 1291-1307
CARF promotes spermatogonial self-renewal and proliferation through Wnt signaling pathway

Wenhao Cui
Xiaoli He
Lin Li
ResearchOpen Access17 Nov 2020
Cell Discovery

Volume: 6, P: 1-13
Identification of P-Rex1 as an anti-inflammatory and anti-fibrogenic target for pulmonary fibrosis

Qing Liang
Ni Cheng
Richard D. Ye
ResearchOpen Access13 May 2016
Scientific Reports

Volume: 6, P: 1-10
Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/β-catenin transcriptional activity

Xiaoli He
Wenjuan Zhang
Lin Li
ResearchOpen Access31 Jan 2017
Cell Discovery

Volume: 3, P: 1-15
Signaling mechanisms for regulation of chemotaxis

Dianqing WU
Reviews01 Jan 2005
Cell Research

Volume: 15, P: 52-56
Pathway-selective suppression of chemokine receptor signaling in B cells by LPS through downregulation of PLC-β2

Aiko-Konno Shirakawa
Fang Liao
Joshua M Farber
Research27 Sept 2010
Cellular & Molecular Immunology

Volume: 7, P: 428-439

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