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Showing 1–3 of 3 results
Advanced filters: Author: Didier A. Bilodeau Clear advanced filters

  • Endonucleases play crucial roles in various biological processes but endonucleases that target small non-coding RNAs have not been reported. Here, the authors combined the metal binding non-canonical amino acid BpyAla and a high affinity binder to engineer a catalyst that degrades small non-coding RNAs.

    • Noreen Ahmed
    • Nadine Ahmed
    • John Paul Pezacki
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • The underlying mechanisms and optimal conditions that drive biorthogonal reactions and the utility of these for applications in medicinal chemistry and protein synthesis to polymers and materials science are described in this Primer. Current reproducibility standards and how current reaction limitations are driving new research efforts are also discussed.

    • Samuel L. Scinto
    • Didier A. Bilodeau
    • Joseph M. Fox
    Reviews
    Nature Reviews Methods Primers
    Volume: 1, P: 1-23