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Advanced filters: Author: Diego Capcha-Rodriguez Clear advanced filters

  • The antiviral dsRNA sensor PKR is regulated by PACT. This paper shows how PACT prevents aberrant PKR activation by endogenous dsRNAs like Alu. PACT disrupts PKR’s dsRNA scanning without blocking its binding, resetting its activation threshold to tolerate cellular dsRNA and preserve homeostasis.

    • Sadeem Ahmad
    • Tao Zou
    • Sun Hur
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17