Nature Search

Direct detection of an NH-π hydrogen bond in an intrinsically disordered peptide

The authors demonstrate a proof-of-principle example of an NH-π hydrogen bond on the surface of an intrinsically disordered protein through detection of weak scalar couplings by NMR, supported by Molecular Dynamics simulation and DFT calculations.

Luigi Russo
Dipendu Dhar
Nasrollah Rezaei-Ghaleh
ResearchOpen Access20 Nov 2025
Nature Communications

Volume: 16, P: 1-11
Oral PRI-002 treatment in patients with MCI or mild AD: a randomized, double-blind phase 1b trial

A randomized, double-blind, placebo-controlled phase 1b study evaluated the safety of the anti-oligomeric PRI-002 in 19 MCI or mild AD patients after 28 d of treatment. Overall, PRI-002 was well tolerated. While no biomarker changes or ARIA were detected, memory improved in the PRI-002 group.

Janine Kutzsche
Nicoleta Carmen Cosma
Oliver Peters
ResearchOpen Access06 May 2025
Nature Communications

Volume: 16, P: 1-9
A near atomic-scale view at the composition of amyloid-beta fibrils by atom probe tomography

Kristiane A. K. Rusitzka
Leigh T. Stephenson
Baptiste Gault
ResearchOpen Access04 Dec 2018
Scientific Reports

Volume: 8, P: 1-10
Cryo-EM of Aβ fibrils from mouse models find tg-APP_ArcSwe fibrils resemble those found in patients with sporadic Alzheimer’s disease

This study by Zielinski et al. used cryo-EM to compare Aβ fibril structures from mouse models to those from patients with Alzheimer’s disease. It revealed that tg-APP_ArcSwe mice exhibit fibrils resembling those predominantly found in sporadic Alzheimer’s disease cases.

Mara Zielinski
Fernanda S. Peralta Reyes
Gunnar F. Schröder
ResearchOpen Access16 Nov 2023
Nature Neuroscience

Volume: 26, P: 2073-2080
Accurate de novo design of high-affinity protein-binding macrocycles using deep learning

A method for de novo design of peptide macrocyles called RFpeptides has been developed. RFpeptides is an extension of RoseTTAFold2 and RFdiffusion and combines structure prediction and protein backbone generation for rapid and custom design of macrocyclic peptide binders.

Stephen A. Rettie
David Juergens
Gaurav Bhardwaj
ResearchOpen Access20 Jun 2025
Nature Chemical Biology

Volume: 21, P: 1948-1956
Direct disassembly of α-syn preformed fibrils into α-syn monomers by an all-D-peptide

Marc Sevenich
Ian Gering
Dieter Willbold
ResearchOpen Access22 Sept 2025
npj Parkinson's Disease

Volume: 11, P: 1-15
Large dynamics of a phase separating arginine-glycine-rich domain revealed via nuclear and electron spins

The authors show the RNA-induced droplet formation by a component of Cajal bodies and reveal the large nanoseconds mobility of glycine residues inside droplets as a molecular factor potentially contributing to the large dynamics of Cajal bodies.

Giuseppe Sicoli
Daniel Sieme
Nasrollah Rezaei-Ghaleh
ResearchOpen Access21 Feb 2024
Nature Communications

Volume: 15, P: 1-12
Quantitative detection of α-Synuclein and Tau oligomers and other aggregates by digital single particle counting

Lara Blömeke
Marlene Pils
Dieter Willbold
ResearchOpen Access02 Jun 2022
npj Parkinson's Disease

Volume: 8, P: 1-13
True-atomic-resolution insights into the structure and functional role of linear chains and low-barrier hydrogen bonds in proteins

High-resolution (≤1.2 Å) structures of functional states of bacteriorhodopsin reveal the molecular mechanism for generating a membrane proton electrochemical gradient, a key event of cell bioenergetics driving ATP synthesis.

Valentin Borshchevskiy
Kirill Kovalev
Valentin Gordeliy
Research28 Apr 2022
Nature Structural & Molecular Biology

Volume: 29, P: 440-450
Artifact detection in fluorescence microscopy using convolutional autoencoder

Fabian Rehn
Marlene Pils
Dieter Willbold
ResearchOpen Access12 Sept 2025
Scientific Reports

Volume: 15, P: 1-12
IAPP - oligomerisation levels in plasma of people with type 2 diabetes

Fabian Rehn
Victoria Kraemer-Schulien
Dieter Willbold
ResearchOpen Access22 Aug 2024
Scientific Reports

Volume: 14, P: 1-9
Viral rhodopsins 1 are an unique family of light-gated cation channels

Nucleocytoplasmic Large DNA Viruses (NCLDV) that infect algae encode two distinct families of microbial rhodopsins. Here, the authors characterise two proteins form the viral rhodopsin group 1 OLPVR1 and VirChR1, present the 1.4 Å crystal structure of OLPVR1 and show that viral rhodopsins 1 are light-gated cation channels.

Dmitrii Zabelskii
Alexey Alekseev
Valentin Gordeliy
ResearchOpen Access11 Nov 2020
Nature Communications

Volume: 11, P: 1-16
Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy

The Src-homology 3 domain of phosphatidyl-inositol-3-kinase (PI3K-SH3) is a model system for studying amyloid fibril formation. Here the authors present the 3.4 Å cryo-EM structure of the PI3K-SH3 amyloid fibril, which allows them to rationalize the effects of mutations on the kinetics of fibril formation.

Christine Röder
Nicola Vettore
Gunnar F. Schröder
ResearchOpen Access21 Aug 2019
Nature Communications

Volume: 10, P: 1-9
Fluorescence correlation spectroscopy reveals a cooperative unfolding of monomeric amyloid-β 42 with a low Gibbs free energy

Mario Schneider
Stefan Walta
Dieter Willbold
ResearchOpen Access19 May 2017
Scientific Reports

Volume: 7, P: 1-8
Structural basis for the inhibition of IAPP fibril formation by the co-chaperonin prefoldin

Integrated kinetic and structural investigations reveal that the ubiquitous co-chaperonin prefoldin interacts with its coiled-coil helices on the islet amyloid polypeptide fibril surface and fibril ends to inhibit fibril elongation and secondary nucleation.

Ricarda Törner
Tatsiana Kupreichyk
Jerome Boisbouvier
ResearchOpen Access02 May 2022
Nature Communications

Volume: 13, P: 1-13
The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors

Long non-coding RNAs (lncRNAs) can contribute to cancers that are driven by Sonic hedgehog (SHH) signaling. Here the authors report that lncRNA HHIP-AS1 stabilises the mRNA of dynein complex 1, thereby, promoting the pro-mitotic effects of SHH-driven tumors.

Jasmin Bartl
Marco Zanini
Marc Remke
ResearchOpen Access13 Jul 2022
Nature Communications

Volume: 13, P: 1-15
Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-β fibrils

Cryo-EM analyses of amyloid fibrils formed by synthetic human IAPP show an S-fold for the main polymorph, with the backbone superimposable with those of amyloid-β fibrils in antiparallel arrangement.

Christine Röder
Tatsiana Kupreichyk
Gunnar F. Schröder
Research15 Jun 2020
Nature Structural & Molecular Biology

Volume: 27, P: 660-667
Crystal structure of a light-driven sodium pump

Crystal structures of the microbial rhodopsin KR2, a recently discovered light-driven sodium pump, reveal the translocation pathway of sodium ions and shed light on the molecular mechanism of ion pumping.

Ivan Gushchin
Vitaly Shevchenko
Valentin Gordeliy
Research06 Apr 2015
Nature Structural & Molecular Biology

Volume: 22, P: 390-395
Observing the overall rocking motion of a protein in a crystal

Small-amplitude overall motion of molecules in crystals limits the achievable resolution in X-ray diffraction, yet little is known about its exact nature. Here, the authors obtain NMR, XRD and MD data from three different crystal forms of a protein (ubiquitin) to gain insight into amplitude and timescale of such motions.

Peixiang Ma
Yi Xue
Paul Schanda
ResearchOpen Access05 Oct 2015
Nature Communications

Volume: 6, P: 1-10
Author Correction: The highly GABARAP specific rat monoclonal antibody 8H5 visualizes GABARAP in immunofluorescence imaging at endogenous levels

Indra M. Simons
Jeannine Mohrlüder
Dieter Willbold
Amendments and CorrectionsOpen Access11 Dec 2019
Scientific Reports

Volume: 9, P: 1
Patients with isolated REM-sleep behavior disorder have elevated levels of alpha-synuclein aggregates in stool

Anja Schaffrath
Sophia Schleyken
Gültekin Tamgüney
ResearchOpen Access02 Feb 2023
npj Parkinson's Disease

Volume: 9, P: 1-11
Blood-based quantification of Aβ oligomers indicates impaired clearance from brain in ApoE ε4 positive subjects

Bloemeke et al. develop a method for measuring Aβ oligomers in plasma to diagnose Alzheimer’s Disease. Correlation analysis between cerebral spinal fluid and plasma oligomer concentrations indicates an impaired clearance of Aβ oligomers that is dependent on ApoE ε4 status.

Lara Blömeke
Fabian Rehn
Dieter Willbold
ResearchOpen Access10 Dec 2024
Communications Medicine

Volume: 4, P: 1-13
The highly GABARAP specific rat monoclonal antibody 8H5 visualizes GABARAP in immunofluorescence imaging at endogenous levels

Indra M. Simons
Jeannine Mohrlüder
Dieter Willbold
ResearchOpen Access24 Jan 2019
Scientific Reports

Volume: 9, P: 1-11
Conformational heterogeneity coupled with β-fibril formation of a scaffold protein involved in chronic mental illnesses

Abhishek Cukkemane
Nina Becker
Oliver H. Weiergräber
ResearchOpen Access17 Dec 2021
Translational Psychiatry

Volume: 11, P: 1-13
Metabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomers

Anne Elfgen
Michelle Hupert
Dieter Willbold
ResearchOpen Access05 Apr 2019
Scientific Reports

Volume: 9, P: 1-13
Solution structure of the autophagy-related protein LC3C reveals a polyproline II motif on a mobile tether with phosphorylation site

Carsten Krichel
Christina Möckel
Philipp Neudecker
ResearchOpen Access02 Oct 2019
Scientific Reports

Volume: 9, P: 1-15
Structure of the SLy1 SAM homodimer reveals a new interface for SAM domain self-association

Laura Kukuk
Andrew J. Dingley
Bernd W. Koenig
ResearchOpen Access10 Jan 2019
Scientific Reports

Volume: 9, P: 1-14
The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology

Thomas van Groen
Sarah Schemmert
Dieter Willbold
ResearchOpen Access24 Nov 2017
Scientific Reports

Volume: 7, P: 1-12
Direct binding to GABARAP family members is essential for HIV-1 Nef plasma membrane localization

Alexandra Boeske
Melanie Schwarten
Dieter Willbold
ResearchOpen Access20 Jul 2017
Scientific Reports

Volume: 7, P: 1-12
QIAD assay for quantitating a compound’s efficacy in elimination of toxic Aβ oligomers

Oleksandr Brener
Tina Dunkelmann
Dieter Willbold
ResearchOpen Access23 Sept 2015
Scientific Reports

Volume: 5, P: 1-13
Structure and dimerization properties of the plant-specific copper chaperone CCH

Dominik Dluhosch
Lisa Sophie Kersten
Georg Groth
ResearchOpen Access17 Aug 2024
Scientific Reports

Volume: 14, P: 1-17
A comparative pharmaco-metabolomic study of glutaminase inhibitors in glioma stem-like cells confirms biological effectiveness but reveals differences in target-specificity

Katharina Koch
Rudolf Hartmann
Ulf D. Kahlert
ResearchOpen Access16 Apr 2020
Cell Death Discovery

Volume: 6, P: 1-14
Aβ42 pentamers/hexamers are the smallest detectable oligomers in solution

Martin Wolff
Bo Zhang-Haagen
Luitgard Nagel-Steger
ResearchOpen Access30 May 2017
Scientific Reports

Volume: 7, P: 1-13
Structural insights from lipid-bilayer nanodiscs link α-Synuclein membrane-binding modes to amyloid fibril formation

Thibault Viennet and colleagues gain structural insight into amyloid fibril formation from their innovative use of lipid bilayer nanodiscs. This study connects α-Synuclein membrane binding modes to its aggregation properties, furthering our understanding of the cause of neurodegerative diseases.

Thibault Viennet
Michael M. Wördehoff
Manuel Etzkorn
ResearchOpen Access03 May 2018
Communications Biology

Volume: 1, P: 1-12
β-Hairpin of Islet Amyloid Polypeptide Bound to an Aggregation Inhibitor

Ewa A. Mirecka
Sophie Feuerstein
Wolfgang Hoyer
ResearchOpen Access19 Sept 2016
Scientific Reports

Volume: 6, P: 1-8
Structure of a LOV protein in apo-state and implications for construction of LOV-based optical tools

Vladimir Arinkin
Joachim Granzin
Renu Batra-Safferling
ResearchOpen Access17 Feb 2017
Scientific Reports

Volume: 7, P: 1-10
The sweet spot: defining virus–sialic acid interactions

Viral infection is induced by binding of the virus to host sialylated glycans on the cell surface. Glycan array studies and structure determination provide new insights into the virus–silaic acid interaction and its functional role in viral disease. This Review highlights principles of glycan binding that are used by influenza virus, reovirus, adenovirus and rotavirus.

Jennifer E. Stencel-Baerenwald
Kerstin Reiss
Terence S. Dermody
Reviews29 Sept 2014
Nature Reviews Microbiology

Volume: 12, P: 739-749

Search

Direct detection of an NH-π hydrogen bond in an intrinsically disordered peptide

Oral PRI-002 treatment in patients with MCI or mild AD: a randomized, double-blind phase 1b trial

A near atomic-scale view at the composition of amyloid-beta fibrils by atom probe tomography

Cryo-EM of Aβ fibrils from mouse models find tg-APP_ArcSwe fibrils resemble those found in patients with sporadic Alzheimer’s disease

Accurate de novo design of high-affinity protein-binding macrocycles using deep learning

Direct disassembly of α-syn preformed fibrils into α-syn monomers by an all-D-peptide

Large dynamics of a phase separating arginine-glycine-rich domain revealed via nuclear and electron spins

Quantitative detection of α-Synuclein and Tau oligomers and other aggregates by digital single particle counting

True-atomic-resolution insights into the structure and functional role of linear chains and low-barrier hydrogen bonds in proteins

Artifact detection in fluorescence microscopy using convolutional autoencoder

IAPP - oligomerisation levels in plasma of people with type 2 diabetes

Viral rhodopsins 1 are an unique family of light-gated cation channels

Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy

Fluorescence correlation spectroscopy reveals a cooperative unfolding of monomeric amyloid-β 42 with a low Gibbs free energy

Structural basis for the inhibition of IAPP fibril formation by the co-chaperonin prefoldin

The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors

Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-β fibrils

Crystal structure of a light-driven sodium pump

Observing the overall rocking motion of a protein in a crystal

Author Correction: The highly GABARAP specific rat monoclonal antibody 8H5 visualizes GABARAP in immunofluorescence imaging at endogenous levels

Patients with isolated REM-sleep behavior disorder have elevated levels of alpha-synuclein aggregates in stool

Blood-based quantification of Aβ oligomers indicates impaired clearance from brain in ApoE ε4 positive subjects

The highly GABARAP specific rat monoclonal antibody 8H5 visualizes GABARAP in immunofluorescence imaging at endogenous levels

Conformational heterogeneity coupled with β-fibril formation of a scaffold protein involved in chronic mental illnesses

Metabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomers

Solution structure of the autophagy-related protein LC3C reveals a polyproline II motif on a mobile tether with phosphorylation site

Structure of the SLy1 SAM homodimer reveals a new interface for SAM domain self-association

The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology

Direct binding to GABARAP family members is essential for HIV-1 Nef plasma membrane localization

QIAD assay for quantitating a compound’s efficacy in elimination of toxic Aβ oligomers

Structure and dimerization properties of the plant-specific copper chaperone CCH

A comparative pharmaco-metabolomic study of glutaminase inhibitors in glioma stem-like cells confirms biological effectiveness but reveals differences in target-specificity

Aβ42 pentamers/hexamers are the smallest detectable oligomers in solution

Structural insights from lipid-bilayer nanodiscs link α-Synuclein membrane-binding modes to amyloid fibril formation

β-Hairpin of Islet Amyloid Polypeptide Bound to an Aggregation Inhibitor

Structure of a LOV protein in apo-state and implications for construction of LOV-based optical tools

The sweet spot: defining virus–sialic acid interactions

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