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Showing 1–8 of 8 results
Advanced filters: Author: Digby F. Warner Clear advanced filters

  • In this Review, Warner, Barczak, Gutierrez and Mizrahi explore essential aspects of Mycobacterium tuberculosis physiology and biology, present recent advances related to its pathogenesis, metabolism and immune evasion mechanisms, and propose future directions for research.

    • Digby F. Warner
    • Amy K. Barczak
    • Valerie Mizrahi
    Reviews
    Nature Reviews Microbiology
    Volume: 23, P: 788-804

  • Dimethyl fumarate (DMF) is an anti-inflammatory drug proposed as a treatment for COVID19. Here the results are reported from a randomised trial testing DMF treatment in 713 patients hospitalised with COVID-19. DMF was not associated with any improvement in day 5 outcomes.

    • Peter Sandercock
    • Janet Darbyshire
    • Martin J. Landray
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Three new studies have used whole-genome sequencing of M. tuberculosis to demonstrate unexpected complexity in the modern evolution of drug-resistant tuberculosis, and a fourth study suggests a close evolutionary relationship between the pathogen and its human host over a period of 70,000 years. Collectively, the observations in these studies suggest that future strategies to tackle drug-resistant tuberculosis must integrate host genetics with detailed strain epidemiology.

    • Digby F Warner
    • Valerie Mizrahi
    News & Views
    Nature Genetics
    Volume: 45, P: 1107-1108

  • Persistence of Mycobacterium tuberculosis in humans depends on its ability to survive within the host macrophage. So the bacterium must resist antimicrobial mechanisms or subvert macrophage signaling pathways to prevent its death. Recent evidence suggests that the two strategies are not mutually exclusive.

    • Digby F Warner
    • Valerie Mizrahi
    News & Views
    Nature Medicine
    Volume: 13, P: 282-284

  • Decoquinate is a drug used in veterinary practice, which displays antimalarial activity in vitro but has poor bioavailability. Here, the authors convert decoquinate into more soluble amide and carbamate derivatives and assess their efficacy against tuberculosis bacteria and apicomplexan parasites.

    • Richard M. Beteck
    • Ronnett Seldon
    • Richard K. Haynes
    ResearchOpen Access
    Communications Chemistry
    Volume: 1, P: 1-11

  • Life scientists in Africa have had limited opportunity to participate in international advanced scientific training programs and workshops, which largely benefit researchers in North America, Europe and the Asia–Pacific region. Here, we chronicle the strategies adopted and challenges encountered in organizing Imaging Africa, an all-expenses-paid, continent-wide practical workshop in optical microscopy hosted in South Africa from 13 to 17 January 2020. Our experience can help steer other groups who similarly seek to organize impactful and sustainable training initiatives in Africa.

    • Michael A. Reiche
    • Digby F. Warner
    • Teng-Leong Chew
    Comments & Opinion
    Nature Methods
    Volume: 18, P: 847-855