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Advanced filters: Author: Dilizhatai Saimi Clear advanced filters

Imaging mitochondrial membrane potential via concentration-dependent fluorescence lifetime changes

Saimi and colleagues present PKMDR, a mitochondrial probe whose fluorescence lifetime serves as an indicator to monitor mitochondrial membrane potential and respiration dynamics with high resolution across cells and tissues.

Dilizhatai Saimi
Luc Reymond
Zhixing Chen
ResearchOpen Access12 Dec 2025
Nature Communications

Volume: 16, P: 1-14
Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1–mucin pathway

Lv et al. reveal a non-canonical role for gasdermin E in protecting pancreatic cancer cells from chymotrypsin-mediated digestion in the microenvironment by promoting the transcription factor YBX1 to induce mucin expression.

Jiadi Lv
Yuying Liu
Bo Huang
ResearchOpen Access15 Mar 2022
Nature Cell Biology

Volume: 24, P: 364-372

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Imaging mitochondrial membrane potential via concentration-dependent fluorescence lifetime changes

Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1–mucin pathway

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