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Showing 1–3 of 3 results
Advanced filters: Author: Dimitar Petrov Clear advanced filters

  • Cyclic peptides are an important drug modality but access to diverse chemical sets of cyclic peptides is difficult on a large library scale. Here, the authors use DNA-encoded library (DEL) technology for the dual-display of two peptidic sub-libraries at the extremities of DNA heteroduplexes and show that varying the level of conformational restraint is essential for the discovery of specific ligands for the three protein targets.

    • Dimitar Petrov
    • Louise Plais
    • Jörg Scheuermann
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Bacterial tRNA is modified by thiolation of nucleosides. Here the authors identify 2-methylthiocytidine in bacterial tRNA using nucleic acid isotope labeling coupled mass spectrometry. Exposure to methylating agents converts 2-thiocytidine to 2-methylthiocytidine, which is repaired by demethylase AlkB in vivo.

    • Valentin F. Reichle
    • Dimitar P. Petrov
    • Stefanie Kellner
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Robust and fast control of the atomic vapor pressure in alkali vapor cells would greatly extend their use for many quantum technologies. Here, the authors exploit plasmonic absorption in a cell coating containing gold nanoparticles to control the vapor pressure with milliseconds response time.

    • Kristina R. Rusimova
    • Dimitar Slavov
    • Ventsislav K. Valev
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-8