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Showing 1–12 of 12 results
Advanced filters: Author: Dimitrios C. Mastellos Clear advanced filters

  • The complement pathway plays key roles in host defence, but its excessive activation or dysregulation can lead to a variety of disorders. This poster overviews strategies to therapeutically intervene in the pathway and the new generation of complement inhibitors that are now in the clinic.

    • Daniel Ricklin
    • Dimitrios C. Mastellos
    • John D. Lambris
    Multimedia
    Nature Reviews Drug Discovery
    P: 1

  • This Review focuses on how the complement cascade can both promote and inhibit antitumour immune responses. The authors discuss the potential of targeting complement components for immunotherapeutic purposes in patients with cancer.

    • Edimara S. Reis
    • Dimitrios C. Mastellos
    • John D. Lambris
    Reviews
    Nature Reviews Immunology
    Volume: 18, P: 5-18

  • Distinct proteolytic pathways share convergent activation patterns in many pathological contexts. Two new studies in Nature report on how effector memory-like CD8+ T cells infiltrate inflamed tissues in various disease states and drive tissue-restricted complement activation via the release of granzyme K.

    • Dimitrios C. Mastellos
    • John D. Lambris
    News & Views
    Nature Immunology
    Volume: 26, P: 647-649

  • This Comment article from Lambris and colleagues considers the therapeutic potential of targeting the complement system in patients with COVID-19.

    • Antonio M. Risitano
    • Dimitrios C. Mastellos
    • John D. Lambris
    Comments & Opinion
    Nature Reviews Immunology
    Volume: 20, P: 343-344

  • Complement activation has important physiological and pathological implications for kidney-related and other diseases. Here, the authors discuss the state of the art of complement therapeutics, including the targets, candidate drugs, insights from clinical trials and evolving challenges for the field.

    • Daniel Ricklin
    • Dimitrios C. Mastellos
    • John D. Lambris
    Reviews
    Nature Reviews Nephrology
    Volume: 14, P: 26-47

  • This Review provides a guide to complement and its emerging roles in processes beyond innate immune defence such as in early development, tissue immunometabolism, tissue regeneration and cancer immunity. Moreover, our improved understanding of its role in disease pathology has opened new options for complement-based therapeutics.

    • Dimitrios C. Mastellos
    • George Hajishengallis
    • John D. Lambris
    Reviews
    Nature Reviews Immunology
    Volume: 24, P: 118-141

  • This Review covers new insights into the immune roles of complement. The authors discuss the pathways that link complement signalling with homeostatic and pathological T cell responses and highlight how complement components act intracellularly to shape T cell responses.

    • Edimara S. Reis
    • Dimitrios C. Mastellos
    • John D. Lambris
    Reviews
    Nature Reviews Immunology
    Volume: 19, P: 503-516

  • The complement system has a pivotal role in immunosurveillance and its dysregulation is involved in a variety of diseases. Here, Lambris and colleagues provide an overview of the pathological roles of the complement system in acute and chronic disorders, assessing recent developments in complement drug discovery, while highlighting the associated opportunities and challenges.

    • Dimitrios C. Mastellos
    • Daniel Ricklin
    • John D. Lambris
    Reviews
    Nature Reviews Drug Discovery
    Volume: 18, P: 707-729

  • Lambris and colleagues discuss new and previously unanticipated functions of complement and how these affect immunity and disease pathogenesis.

    • George Hajishengallis
    • Edimara S Reis
    • John D Lambris
    Reviews
    Nature Immunology
    Volume: 18, P: 1288-1298