Kinases are attractive drug targets, but the design of highly selective kinase inhibitors remains challenging. Here, the authors report photoaffinity probes based on the imidazopyrazine scaffold, which is found in several kinase inhibitors and drugs or drug candidates, and use proteome selectivity profiling to show the varying off-target profiles of different probes.
- Dimitris Korovesis
- Christel Mérillat
- Steven H. L. Verhelst
