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Showing 1–10 of 10 results
Advanced filters: Author: Dina Grohmann Clear advanced filters

  • TATA-binding protein (TBP) and a transcription factor (TF) IIB-like factor are important constituents of all eukaryotic initiation complexes. Here, the authors use a DNA origami-based force clamp to investigate the assembly dynamics of human initiation complexes in the RNAP II and RNAP III systems at the single-molecule level under pico newton forces.

    • Kevin Kramm
    • Tim Schröder
    • Dina Grohmann
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • In an iron-sulfide chemical garden experiment that mimics the kind of hydrothermal vents that might have occurred in the early Archaean, mackinawite and greigite are precipitated and abiotic H2 is produced in sufficient quantities to support exponential growth of a hyperthermophilic and hydrogenotrophic methanogen, Methanocaldococcus jannaschii.

    • Vanessa Helmbrecht
    • Robert Reichelt
    • William D. Orsi
    ResearchOpen Access
    Nature Ecology & Evolution
    Volume: 9, P: 769-778

  • RNA polymerase is an ancient enzyme that is present in all cellular life. Werner and Grohmann provide an evolutionary view of this enzyme by describing the differences and similarities in the three domains of life, and propose a hypothesis for the evolution of transcriptional regulation.

    • Finn Werner
    • Dina Grohmann
    Reviews
    Nature Reviews Microbiology
    Volume: 9, P: 85-98

  • How archaeal viruses perturb host transcription machinery is poorly understood. Here, the authors provide evidence that the archaeo-viral transcription factor ORF145/RIP targets host RNA polymerase, repressing its activity.

    • Carol Sheppard
    • Fabian Blombach
    • Finn Werner
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Crystal structures of the Argonaute protein from the archaeon Methanocaldococcus jannaschii (MjAgo) in its apo state and bound to a guide DNA elucidate the molecular mechanisms that drive DNA-guided DNA silencing in Archaea.

    • Sarah Willkomm
    • Christine A. Oellig
    • Sabine Schneider
    Research
    Nature Microbiology
    Volume: 2, P: 1-7

  • Transcription initiation by RNA polymerase III requires TFIIIB, a complex formed by Brf1/Brf2, TBP and Bdp1. Here, the authors describe the crystal structure of a Brf2-TBP-Bdp1 complex bound to a DNA promoter and characterize the role of Bdp1 in TFIIIB assembly and pre-initiation complex formation.

    • Jerome Gouge
    • Nicolas Guthertz
    • Alessandro Vannini
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11