Nature Search

A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients

Nardone et al. identify a metazoan protein complex (mRAVE) that assembles V-ATPases from two subcomplexes, enabling lysosome acidification, neurotransmitter vesicle loading and a lysosome damage response pathway.

Christopher Nardone
Julian Mintseris
Tom Rapoport
ResearchOpen Access11 Jul 2025
Nature Structural & Molecular Biology

Volume: 32, P: 2076-2087
Pseudomonas aeruginosa SutA wedges RNAP lobe domain open to facilitate promoter DNA unwinding

SutA is a transcription factor which increases transcription activity of an RNA polymerase (RNAP). Here, authors present cryo-EM structures of SutA-bound RNAP-σ^S holoenzyme and SutA-bound transcription initiation complex, which reveals SutA wedging the RNAP-β lobe open to aid unwinding.

Dingwei He
Linlin You
Yu Zhang
ResearchOpen Access20 Jul 2022
Nature Communications

Volume: 13, P: 1-10
DEM simulation of earth pressure mobilisation with active retaining wall movements

Dingwei He
Jikai Guo
Liang Cui
ResearchOpen Access30 Sept 2025
Scientific Reports

Volume: 15, P: 1-14
Single-cell analysis unravels divergent gene signatures shaping seminoma stemness and metastasis

Zhouliang Bian
Biying Chen
Yanjie Zhang
ResearchOpen Access07 Nov 2025
Cell Death Discovery

Volume: 11, P: 1-13
Enabling low-drift flexible perovskite photodetectors by electrical modulation for wearable health monitoring and weak light imaging

Defects and ion migration in perovskites hinder their potential as active material for flexible photodetectors. Here, the authors provide an electrical field modulation strategy to enhance the operational stability and the signal-to-noise ratio of flexible perovskite photodetectors.

Yingjie Tang
Peng Jin
Bowen Zhu
ResearchOpen Access16 Aug 2023
Nature Communications

Volume: 14, P: 1-10
First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial

In the homologous recombination repair-deficient population of TALAPRO-2, a placebo-controlled phase 3 trial, treatment of patients with metastatic castration-resistant prostate cancer with the poly(ADP-ribose) polymerase inhibitor talazoparib plus enzalutamide led to prolonged progression-free survival compared with placebo plus enzalutamide.

Karim Fizazi
Arun A. Azad
Neeraj Agarwal
ResearchOpen Access04 Dec 2023
Nature Medicine

Volume: 30, P: 257-264
Structural basis for intrinsic transcription termination

Structural studies of Escherichia coli transcription intrinsic termination complexes representing distinct intermediates using cryo-electron microscopy provide insights into the steps and mechanism of transcription termination.

Linlin You
Expery O. Omollo
Yu Zhang
Research11 Jan 2023
Nature

Volume: 613, P: 783-789
SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition

Geminin-Cdt1 plays essential roles in the regulation of DNA replication. Here the authors reveal that the CULLIN3 E3 ubiquitin ligase adaptor protein SPOP prevents DNA replication over-firing and genome instability by affecting Geminin ubiquitination.

Jian Ma
Qing Shi
Haojie Huang
ResearchOpen Access01 Oct 2021
Nature Communications

Volume: 12, P: 1-14
A comparison of NBI and WLI cystoscopy in detecting non-muscle-invasive bladder cancer: A prospective, randomized and multi-center study

Zhangqun Ye
Jia Hu
Dongwen Wang
ResearchOpen Access05 Jun 2015
Scientific Reports

Volume: 5, P: 1-6
FOXA1-dependent NSUN2 facilitates the advancement of prostate cancer by preserving TRIM28 mRNA stability in a m5C-dependent manner

Zhenda Wang
Abudurexiti Mierxiati
Dingwei Ye
ResearchOpen Access03 May 2025
npj Precision Oncology

Volume: 9, P: 1-16
Comprehensive analysis of the LINC01122/TPD52 axis as a predictive biomarker in prostate adenocarcinoma

Zhi Shang
Shengming Jin
Dingwei Ye
ResearchOpen Access08 May 2025
Scientific Reports

Volume: 15, P: 1-15
Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4

Yinghao Sun and colleagues report a genome-wide association study for prostate cancer in Han Chinese men. They identify two new risk-associated loci at chromosomes 9q31 and 19q13.

Jianfeng Xu
Zengnan Mo
Yinghao Sun
Research30 Sept 2012
Nature Genetics

Volume: 44, P: 1231-1235
Role of gut microbiota in the pathogenesis of castration-resistant prostate cancer: a comprehensive study using sequencing and animal models

Guowen Lin
Feng Zhang
Gangmin Wang
Research17 Jun 2024
Oncogene

Volume: 43, P: 2373-2388
Patient-reported outcomes of rezvilutamide versus bicalutamide in combination with androgen deprivation therapy in high-volume metastatic hormone-sensitive prostate cancer patients (CHART): a randomized, phase 3 study

Hongkai Wang
Shusuan Jiang
Dingwei Ye
ResearchOpen Access18 Dec 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-9
A potential strategy for bladder cancer treatment: inhibiting autophagy to enhance antitumor effects of Nectin-4-MMAE

Yichen Wang
Yanyang Nan
Xuyao Zhang
ResearchOpen Access25 Apr 2024
Cell Death & Disease

Volume: 15, P: 1-10
A novel cytotherapy device for rapid screening, enriching and combining mesenchymal stem cells into a biomaterial for promoting bone regeneration

Yifu Zhuang
Yaokai Gan
Kerong Dai
ResearchOpen Access13 Nov 2017
Scientific Reports

Volume: 7, P: 1-11
Targeting HIC1/TGF-β axis-shaped prostate cancer microenvironment restrains its progression

Tianqi Wu
Wenfeng Wang
Jianhua Wang
ResearchOpen Access19 Jul 2022
Cell Death & Disease

Volume: 13, P: 1-17
Diagnosis of adults Xp11.2 translocation renal cell carcinoma by immunohistochemistry and FISH assays: clinicopathological data from ethnic Chinese population

Yuanyuan Qu
Chengyuan Gu
Dingwei Ye
ResearchOpen Access16 Feb 2016
Scientific Reports

Volume: 6, P: 1-9
Neutrophil extracellular traps impair intestinal barrier functions in sepsis by regulating TLR9-mediated endoplasmic reticulum stress pathway

Shilong Sun
Zehua Duan
Weiwei Ding
ResearchOpen Access11 Jun 2021
Cell Death & Disease

Volume: 12, P: 1-12
Hot-band absorption of indocyanine green for advanced anti-stokes fluorescence bioimaging

Hot-band absorption based anti-Stokes fluorescence of ICG for evaluating the thermal state of the tumor and multi-organ imaging.

Jing Zhou
Xiaoxiao Fan
Jun Qian
ResearchOpen Access13 Sept 2021
Light: Science & Applications

Volume: 10, P: 1-12
De-escalation antibiotic therapy alleviates organ injury through modulation of NETs formation during sepsis

Zehua Duan
Tian Xie
Weiwei Ding
ResearchOpen Access10 Nov 2021
Cell Death Discovery

Volume: 7, P: 1-9

Search

A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients

Pseudomonas aeruginosa SutA wedges RNAP lobe domain open to facilitate promoter DNA unwinding

DEM simulation of earth pressure mobilisation with active retaining wall movements

Single-cell analysis unravels divergent gene signatures shaping seminoma stemness and metastasis

Enabling low-drift flexible perovskite photodetectors by electrical modulation for wearable health monitoring and weak light imaging

First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial

Structural basis for intrinsic transcription termination

SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition

A comparison of NBI and WLI cystoscopy in detecting non-muscle-invasive bladder cancer: A prospective, randomized and multi-center study

FOXA1-dependent NSUN2 facilitates the advancement of prostate cancer by preserving TRIM28 mRNA stability in a m5C-dependent manner

Comprehensive analysis of the LINC01122/TPD52 axis as a predictive biomarker in prostate adenocarcinoma

Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4

Role of gut microbiota in the pathogenesis of castration-resistant prostate cancer: a comprehensive study using sequencing and animal models

Patient-reported outcomes of rezvilutamide versus bicalutamide in combination with androgen deprivation therapy in high-volume metastatic hormone-sensitive prostate cancer patients (CHART): a randomized, phase 3 study

A potential strategy for bladder cancer treatment: inhibiting autophagy to enhance antitumor effects of Nectin-4-MMAE

A novel cytotherapy device for rapid screening, enriching and combining mesenchymal stem cells into a biomaterial for promoting bone regeneration

Targeting HIC1/TGF-β axis-shaped prostate cancer microenvironment restrains its progression

Diagnosis of adults Xp11.2 translocation renal cell carcinoma by immunohistochemistry and FISH assays: clinicopathological data from ethnic Chinese population

Neutrophil extracellular traps impair intestinal barrier functions in sepsis by regulating TLR9-mediated endoplasmic reticulum stress pathway

Hot-band absorption of indocyanine green for advanced anti-stokes fluorescence bioimaging

De-escalation antibiotic therapy alleviates organ injury through modulation of NETs formation during sepsis

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