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Showing 1–4 of 4 results
Advanced filters: Author: Dirk A. Kleinjan Clear advanced filters

  • Deactivated Cas9 fused to transactivation domains can be used to control gene expression, however its presence can prevent rapid switching between different regulatory states. Here the authors generate conditionally degradable dCas9 and Cpf1 proteins for multidimensional control of functional activity.

    • Dirk A. Kleinjan
    • Caroline Wardrope
    • Susan J. Rosser
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • A new study shows that a deletion-induced aberrant antisense transcript from a neighboring gene leads to methylation and silencing of the intact gene HBA2 (encoding human α-globin A2) in a family with α-thalassemia. Are there other chromosomal rearrangements that might turn off genes by such antisense-mediated cis-acting methylation?

    • Dirk A Kleinjan
    • Veronica van Heyningen
    News & Views
    Nature Genetics
    Volume: 34, P: 125-126

  • Stanislas Lyonnet and colleagues report a new locus associated with Pierre Robin sequence, an important subgroup of cleft palate. They find that translocations, deletions and point mutation affecting highly conserved noncoding elements (HCNEs) found at distances on either side of SOX9 are associated with PRS.

    • Sabina Benko
    • Judy A Fantes
    • Stanislas Lyonnet
    Research
    Nature Genetics
    Volume: 41, P: 359-364