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Showing 1–13 of 13 results
Advanced filters: Author: Dirk Foell Clear advanced filters

  • Insulin replacement is a valuable therapy for insulin deficiency, however, other therapies are being investigated to restore metabolic homeostasis. Here, the authors identify S100A9 as a leptin induced circulating cue that improves glucose and lipid homeostasis and extends survival in insulin deficient mice.

    • Giorgio Ramadori
    • Sanda Ljubicic
    • Roberto Coppari
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Damage-associated molecular pattern molecules, such as heat shock proteins and S100 proteins, represent tissue danger signals, which mediate inflammatory responses after being released from activated or necrotic cells. These danger signals, and their receptors, could be targets for novel approaches in the treatment of rheumatic diseases, as discussed in this article.

    • Dirk Foell
    • Helmut Wittkowski
    • Johannes Roth
    Reviews
    Nature Clinical Practice Rheumatology
    Volume: 3, P: 382-390

  • During tissue injury blood cells in the microvasculature and tissue resident cells have differing phenotypes. Here the authors use single cell transcriptomics in mice models to assess the differences in phenotype of immune cells in multiple organs and the tissue resident cells before, after and during acute kidney infection.

    • Rebecca Rixen
    • Paula Schütz
    • Konrad Buscher
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • In a mouse model of systemic autoimmunity, the damage-associated molecular pattern molecules Mrp8 and Mrp14 are essential for the induction of autoreactive CD8+ T cells and for disease development in a TLR4– and IL-17–dependent manner. A similar mechanism might be at play in people with cutaneous lupus erythematosus.

    • Karin Loser
    • Thomas Vogl
    • Stefan Beissert
    Research
    Nature Medicine
    Volume: 16, P: 713-717

  • New criteria have been proposed to enable a rapid diagnosis of cryopyrin-associated periodic syndromes (CAPS) in children and adults. Will these diagnostic criteria advance the management of autoinflammatory syndromes, or will physicians now think of zebras rather than horses when they hear hoofbeats?

    • Claas Hinze
    • Dirk Foell
    News & Views
    Nature Reviews Rheumatology
    Volume: 13, P: 7-8

  • Fibroblast-like synoviocytes are important mediators of joint pathology in rheumatoid arthritis (RA). Here the authors show that Lasp1 is epigenetically regulated and highly expressed by these cells in RA and its deletion can limit joint pathology in a mouse model of inflammatory arthritis.

    • Denise Beckmann
    • Anja Römer-Hillmann
    • Adelheid Korb-Pap
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Inflammation can be initiated by exogenous pathogen-associated molecular patterns (PAMPs) or by endogenous damage-associated molecular patters (DAMPs), but the contribution of each activation mechanism to reduction–oxidation (redox) stress and, ultimately, to the immunopathogenesis of autoinflammatory diseases remains elusive. In this Review, Varga and colleagues discuss how improved knowledge of mechanisms of inflammation initiation and propagation might help identify new therapeutic targets for patients with autoinflammatory diseases.

    • Georg Varga
    • Marco Gattorno
    • Anna Rubartelli
    Reviews
    Nature Reviews Rheumatology
    Volume: 11, P: 670-680

  • The treatment of juvenile idiopathic arthritis (JIA) has improved markedly in past years, but sustained remission off-medication is still rare. In this Review, Hinze et al. discuss existing treatment approaches and guidelines, with a focus on targeted and patient-centred therapies developed to optimize management strategies for patients with JIA.

    • Claas Hinze
    • Faekah Gohar
    • Dirk Foell
    Reviews
    Nature Reviews Rheumatology
    Volume: 11, P: 290-300

  • Treatment of ‘classic’ systemic juvenile idiopathic arthritis (sJIA) is evolving markedly, and treatment options for early sJIA without arthritis, and refractory or complicated sJIA are not well defined. This Review outlines current approaches and provides an outlook on knowledge gaps.

    • Claas H. Hinze
    • Dirk Foell
    • Christoph Kessel
    Reviews
    Nature Reviews Rheumatology
    Volume: 19, P: 778-789