Spiegelmers are ‘mirror image’ L-ribose oligonucleotides being developed as therapeutics. Here the authors present a crystal structure of the therapeutic L-aptamer NOX-E36 bound to the pro-inflammatory chemokine CLL2, providing insight into NOX-E36’s selectivity and mode of action.
- Dominik Oberthür
- John Achenbach
- Christian Betzel
