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Biosynthesis and function of magnetic organelles in magnetotactic bacteria

In this Review, Schüler and colleagues summarize our current knowledge of magnetosome formation and organization within the cell, and they explore their function, diversity and potential applications.

Dirk Schüler
Marina Dziuba
René Uebe
Reviews19 Sept 2025
Nature Reviews Microbiology

P: 1-15
Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue

The soluble bioactive form of the transmembrane protein fibronectin type III domain containing 4 (sFNDC4) has anti-inflammatory effects and improves insulin sensitivity. Here the authors show that liver derived sFNDC4 signals through adipose tissue GPCR GPR116 to promote insulin-mediated glucose uptake.

Anastasia Georgiadi
Valeria Lopez-Salazar
Stephan Herzig
ResearchOpen Access20 May 2021
Nature Communications

Volume: 12, P: 1-21
Exploring the host range for genetic transfer of magnetic organelle biosynthesis

Biosynthesis of magnetosomes is of interest for a range of applications. Here, factors needed for magnetosome biosynthesis are evaluated and new diverse bacteria are engineered to biofabricate magnetic nanoparticles, facilitating translation to biotechnology and nanomedicine.

Marina V. Dziuba
Frank-Dietrich Müller
Dirk Schüler
Research21 Sept 2023
Nature Nanotechnology

Volume: 19, P: 115-123
Correction: Corrigendum: An acidic protein aligns magnetosomes along a filamentous structure in magnetotactic bacteria

André Scheffel
Manuela Gruska
Dirk Schüler
Amendments and Corrections11 May 2006
Nature

Volume: 441, P: 248
Magnetosome biogenesis in magnetotactic bacteria

Magnetosomes are unique organelles that 'magnetize' bacteria. In this Review, Uebe and Schüler discuss our current understanding of the mechanisms of magnetosome biogenesis, and consider how recent genetic advances in this area may lead to the development of exciting biotechnological applications.

René Uebe
Dirk Schüler
Reviews13 Sept 2016
Nature Reviews Microbiology

Volume: 14, P: 621-637
An acidic protein aligns magnetosomes along a filamentous structure in magnetotactic bacteria

André Scheffel
Manuela Gruska
Dirk Schüler
Research20 Nov 2005
Nature

Volume: 440, P: 110-114
Biosynthesis of magnetic nanostructures in a foreign organism by transfer of bacterial magnetosome gene clusters

Magnetic nanoparticles are synthesized in a foreign host after gene transfer from magnetotactic bacteria.

Isabel Kolinko
Anna Lohße
Dirk Schüler
Research23 Feb 2014
Nature Nanotechnology

Volume: 9, P: 193-197
Polarity of bacterial magnetotaxis is controlled by aerotaxis through a common sensory pathway

Magnetotactic bacteria sense and migrate along the geomagnetic field, but the molecular mechanism for directed motion is not known. Here, Popp et al. show that M. gryphiswaldensedisplays swimming polarity in an oxygen gradient sensed by the chemotactic sensory pathway CheOp1, revealing a link between aerotactic sensing and magnetotactic polarity.

Felix Popp
Judith P. Armitage
Dirk Schüler
Research14 Nov 2014
Nature Communications

Volume: 5, P: 1-9
MamY is a membrane-bound protein that aligns magnetosomes and the motility axis of helical magnetotactic bacteria

Magnetotactic bacteria must assemble magnetosomes into a linear chain that orients the cell along magnetic fields, yet how spiral bacteria with highly curved surfaces accomplish this is unclear. Here, MamY is shown to assemble into linear structures that serve as a scaffold for magnetosomes in magnetotactic spirilla.

Mauricio Toro-Nahuelpan
Giacomo Giacomelli
Frank-Dietrich Müller
Research29 Jul 2019
Nature Microbiology

Volume: 4, P: 1978-1989
Silent gene clusters encode magnetic organelle biosynthesis in a non-magnetotactic phototrophic bacterium

M. V. Dziuba
A. Paulus
D. Schüler
ResearchOpen Access14 Dec 2022
The ISME Journal

Volume: 17, P: 326-339
The in vivo mechanics of the magnetotactic backbone as revealed by correlative FLIM-FRET and STED microscopy

Erika Günther
André Klauß
Damien Faivre
ResearchOpen Access23 Dec 2019
Scientific Reports

Volume: 9, P: 1-9
Disease-Homologous Mutation in the Cation Diffusion Facilitator Protein MamM Causes Single-Domain Structural Loss and Signifies Its Importance

Shiran Barber-Zucker
René Uebe
Raz Zarivach
ResearchOpen Access23 Aug 2016
Scientific Reports

Volume: 6, P: 1-11
Functional characterization of polysaccharide utilization loci in the marine Bacteroidetes ‘Gramella forsetii’ KT0803

Antje Kabisch
Andreas Otto
Thomas Schweder
ResearchOpen Access13 Feb 2014
The ISME Journal

Volume: 8, P: 1492-1502

Search

Biosynthesis and function of magnetic organelles in magnetotactic bacteria

Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue

Exploring the host range for genetic transfer of magnetic organelle biosynthesis

Correction: Corrigendum: An acidic protein aligns magnetosomes along a filamentous structure in magnetotactic bacteria

Magnetosome biogenesis in magnetotactic bacteria

An acidic protein aligns magnetosomes along a filamentous structure in magnetotactic bacteria

Biosynthesis of magnetic nanostructures in a foreign organism by transfer of bacterial magnetosome gene clusters

Polarity of bacterial magnetotaxis is controlled by aerotaxis through a common sensory pathway

MamY is a membrane-bound protein that aligns magnetosomes and the motility axis of helical magnetotactic bacteria

Silent gene clusters encode magnetic organelle biosynthesis in a non-magnetotactic phototrophic bacterium

The in vivo mechanics of the magnetotactic backbone as revealed by correlative FLIM-FRET and STED microscopy

Disease-Homologous Mutation in the Cation Diffusion Facilitator Protein MamM Causes Single-Domain Structural Loss and Signifies Its Importance

Functional characterization of polysaccharide utilization loci in the marine Bacteroidetes ‘Gramella forsetii’ KT0803

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