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Showing 1–3 of 3 results
Advanced filters: Author: Dmitri Chilov Clear advanced filters

  • Astrocytes in the brain are metabolically dynamic. Here, Ignatenko, Chilov and colleagues delete mitochondrial DNA (mtDNA) in a cell type specific manner, and show that inactivation of mtDNA helicase Twinkle in astrocytes leads to spongiotic encephalopathy.

    • Olesia Ignatenko
    • Dmitri Chilov
    • Anu Suomalainen
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • This work shows a distinct involvement of the meningeal layers in CNS autoimmunity. In animal models and in patients with multiple sclerosis, the leptomeninges were highly inflamed and showed structural changes, while the dura was only marginally affected.

    • Arianna Merlini
    • Michael Haberl
    • Francesca Odoardi
    Research
    Nature Neuroscience
    Volume: 25, P: 887-899