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Showing 1–3 of 3 results
Advanced filters: Author: Dmitrii Degtev Clear advanced filters

  • CRISPR systems entered clinic for therapeutic genome editing, but safety concerns remain. Here, Degtev, Bravo et al. engineer the PsCas9 enzyme, achieving high editing efficacy and maintaining high-fidelity properties, introducing it as a promising tool for safe in vivo genome editing applications.

    • Dmitrii Degtev
    • Jack Bravo
    • Grzegorz Sienski
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • SpCas9 unintended editing is a major concern. Here the authors report an off-target method using Duplex Sequencing with increased sensitivity for Cas9 mutation detection; they also identify a Cas9 variant of the II-B subfamily with intrinsic high fidelity (PsCas9) and see improved specificity.

    • Burcu Bestas
    • Sandra Wimberger
    • Marcello Maresca
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15