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Showing 1–2 of 2 results
Advanced filters: Author: Dmitry Borkin Clear advanced filters

  • The histone methyltransferase ASH1L plays a role in various diseases, including cancer, and has been validated as a therapeutic target; however, no inhibitors of ASH1L have been reported. Here the authors present small molecule inhibitors of ASH1L and demonstrate their on-target activity in leukemia cells and a mouse model of leukemia.

    • David S. Rogawski
    • Jing Deng
    • Jolanta Grembecka
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14