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Showing 1–2 of 2 results
Advanced filters: Author: Dmitry Nevozhay Clear advanced filters

  • Gene circuits created by synthetic biologists working in one system may not be functional when transferred to a different organism. Using computational modelling to identify factors underlying such differences, the authors successfully adapt a yeast ‘linearizer’ circuit so that it functions in mammalian cells.

    • Dmitry Nevozhay
    • Tomasz Zal
    • Gábor Balázsi
    Research
    Nature Communications
    Volume: 4, P: 1-11

  • The role of gene expression noise in the evolution of drug resistance in mammalian cells is unclear. Here, by uncoupling noise from mean expression of a drug resistance gene in CHO cells the authors show that noisy expression aids adaptation to high drug levels, but delays it at low drug levels.

    • Kevin S. Farquhar
    • Daniel A. Charlebois
    • Gábor Balázsi
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14