NF-κB activity is positively regulated through phosphorylation, but how activation is reversed has been unclear. A genome-wide siRNA screen reveals that the phosphatase WIP1 dephosphorylates the NF-κB subunit p65 at Ser 536, a phospho-residue critical for transcriptional regulation.
- Joanne Chew
- Subhra Biswas
- Vinay Tergaonkar