Nature Search

Using the pimeloyl-CoA synthetase adenylation fold to synthesize fatty acid thioesters

Structures of pimeloyl-CoA synthetase (BioW) provide insights into its catalytic mechanism and how it selects the correct length of dicarboxylic acid substrate, guiding engineering to make the enzyme capable of producing alternative CoA products.

Menglu Wang
Lucile Moynié
Dominic J Campopiano
Research17 Apr 2017
Nature Chemical Biology

Volume: 13, P: 660-667
Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England

Genetic and testing data from England show that the SARS-CoV-2 variant of concern B.1.1.7 has a transmission advantage over other lineages.

Erik Volz
Swapnil Mishra
Neil M. Ferguson
Research25 Mar 2021
Nature

Volume: 593, P: 266-269
Arrayed CRISPR libraries for the genome-wide activation, deletion and silencing of human protein-coding genes

Arrayed CRISPR libraries with each plasmid encoding an array of four non-overlapping single-guide RNAs allow for the efficient genome-wide ablation, activation and epigenetic silencing of human protein-coding genes.

Jiang-An Yin
Lukas Frick
Adriano Aguzzi
ResearchOpen Access04 Dec 2024
Nature Biomedical Engineering

Volume: 9, P: 127-148
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

In this study, Aggarwal and colleagues perform prospective sequencing of SARS-CoV-2 isolates derived from asymptomatic student screening and symptomatic testing of students and staff at the University of Cambridge. They identify important factors that contributed to within university transmission and onward spread into the wider community.

Dinesh Aggarwal
Ben Warne
Ian G. Goodfellow
ResearchOpen Access08 Feb 2022
Nature Communications

Volume: 13, P: 1-16
Oceanic nickel depletion and a methanogen famine before the Great Oxidation Event

A decrease in atmospheric methane levels might have triggered the progressive rise of atmospheric oxygen about 2.4 billion years ago, but the cause of this methane decrease remains uncertain. Kurt Konhauser and colleagues report a decline in the oceanic nickel-to-iron ratio about 2.7 billion years ago, which they attribute to a reduced flux of nickel to the oceans; this decline would have stifled the activity of methane-producing organisms that require nickel to function.

Kurt O. Konhauser
Ernesto Pecoits
Balz S. Kamber
Research09 Apr 2009
Nature

Volume: 458, P: 750-753
Quantum simulation of exact electron dynamics can be more efficient than classical mean-field methods

It is often assumed that systems that can be analyzed accurately via mean-field theory would not be worth looking at using quantum algorithms, given entanglement plays no key role. Here, the authors show instead that a quantum advantage can be expected for simulating the exact time evolution of such electronic systems.

Ryan Babbush
William J. Huggins
Joonho Lee
ResearchOpen Access10 Jul 2023
Nature Communications

Volume: 14, P: 1-9
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
Genomic reconstruction of the SARS-CoV-2 epidemic in England

A study of the evolution of the SARS-CoV-2 virus in England between September 2020 and June 2021 finds that interventions capable of containing previous variants were insufficient to stop the more transmissible Alpha and Delta variants.

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
ResearchOpen Access14 Oct 2021
Nature

Volume: 600, P: 506-511
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission

Post-international travel quarantine has been widely implemented to mitigate SARS-CoV-2 transmission, but the impacts of such policies are unclear. Here, the authors used linked genomic and contact tracing data to assess the impacts of a 14-day quarantine on return to England in summer 2020.

Dinesh Aggarwal
Andrew J. Page
Ewan M. Harrison
ResearchOpen Access23 Feb 2022
Nature Communications

Volume: 13, P: 1-13
Approaching optimal entangling collective measurements on quantum computing platforms

Multi-parameter metrology requires collective measurements on more than one copy of the same quantum state. Now, an optimal scheme for the estimation of qubit rotations has been demonstrated on superconducting and trapped-ion platforms.

Lorcán O. Conlon
Tobias Vogl
Syed M. Assad
ResearchOpen Access12 Jan 2023
Nature Physics

Volume: 19, P: 351-357
Further improving quantum algorithms for nonlinear differential equations via higher-order methods and rescaling

Pedro C. S. Costa
Philipp Schleich
Dominic W. Berry
ResearchOpen Access18 Aug 2025
npj Quantum Information

Volume: 11, P: 1-14
Quantum optics on a chip

Researchers have demonstrated a reconfigurable photonic circuit on a chip that can create a four-photon entangled state. The scalability and compactness of the device opens the door towards practical quantum computation.

Dominic W. Berry
Howard M. Wiseman
News & Views01 Jun 2009
Nature Photonics

Volume: 3, P: 317-319
Information Causality in the Quantum and Post-Quantum Regime

Martin Ringbauer
Alessandro Fedrizzi
Andrew G. White
ResearchOpen Access07 Nov 2014
Scientific Reports

Volume: 4, P: 1-6
Experimental optical phase measurement approaching the exact Heisenberg limit

Measurements of an unknown optical phase have not yet been performed with the ultimate precision, i.e. saturating the Heisenberg limit. Here, Daryanoosh et al. demonstrate this with a precision within 4% of the Heisenberg limit by combining photonic entanglement and multiple passes.

Shakib Daryanoosh
Sergei Slussarenko
Geoff J. Pryde
ResearchOpen Access02 Nov 2018
Nature Communications

Volume: 9, P: 1-6
Metabolic control of BRISC–SHMT2 assembly regulates immune signalling

Cryo-electron microscopy and mutation experiments demonstrate that the inactive SHMT2 dimer—and not the pyridoxal-5′-phosphate-bound tetramer—binds to BRISC, which reveals a mechanism for the regulation of deubiquitylases and inflammatory signalling.

Miriam Walden
Lei Tian
Elton Zeqiraj
Research29 May 2019
Nature

Volume: 570, P: 194-199
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

The Omicron variant evades vaccine-induced neutralization but also fails to form syncytia, shows reduced replication in human lung cells and preferentially uses a TMPRSS2-independent cell entry pathway, which may contribute to enhanced replication in cells of the upper airway. Altered fusion and cell entry characteristics are linked to distinct regions of the Omicron spike protein.

Brian J. Willett
Joe Grove
Emma C. Thomson
ResearchOpen Access07 Jul 2022
Nature Microbiology

Volume: 7, P: 1161-1179
A gene expression database for the molecular pharmacology of cancer

Uwe Scherf
Douglas T. Ross
John N. Weinstein
Research01 Mar 2000
Nature Genetics

Volume: 24, P: 236-244
The Heisenberg limit for laser coherence

The coherence of a close-to-ideal laser beam can be quadratically better than what was believed to be the quantum limit. This new Heisenberg limit could be attained with circuit quantum electrodynamics.

Travis J. Baker
Seyed N. Saadatmand
Howard M. Wiseman
Research26 Oct 2020
Nature Physics

Volume: 17, P: 179-183
Quantum simulation of realistic materials in first quantization using non-local pseudopotentials

Dominic W. Berry
Nicholas C. Rubin
Ryan Babbush
ResearchOpen Access19 Dec 2024
npj Quantum Information

Volume: 10, P: 1-29
Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
Amendments and CorrectionsOpen Access07 Jun 2022
Nature

Volume: 606, P: E18
Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E24
Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E23
An ab initio study on resistance switching in hexagonal boron nitride

Fabian Ducry
Dominic Waldhoer
Mathieu Luisier
ResearchOpen Access05 Sept 2022
npj 2D Materials and Applications

Volume: 6, P: 1-10
An immunoinformatics study reveals a new BoLA-DR-restricted CD4+ T cell epitopes on the Gag protein of bovine leukemia virus

Aneta Pluta
Tasia Marie Taxis
Jacek Kuźmak
ResearchOpen Access15 Dec 2023
Scientific Reports

Volume: 13, P: 1-22
Improved techniques for preparing eigenstates of fermionic Hamiltonians

Dominic W. Berry
Mária Kieferová
Ryan Babbush
ResearchOpen Access02 May 2018
npj Quantum Information

Volume: 4, P: 1-7
Quantum simulation of chemistry with sublinear scaling in basis size

Ryan Babbush
Dominic W. Berry
Hartmut Neven
ResearchOpen Access01 Nov 2019
npj Quantum Information

Volume: 5, P: 1-7
Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Brian J. Willett
Joe Grove
Emma C. Thomson
Amendments and CorrectionsOpen Access16 Sept 2022
Nature Microbiology

Volume: 7, P: 1709
COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study

Kerstin Kläser
Erika Molteni
Emma L. Duncan
ResearchOpen Access28 Jun 2022
Scientific Reports

Volume: 12, P: 1-17
Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning

Sema Nickbakhsh
Joseph Hughes
Alison Smith-Palmer
ResearchOpen Access19 Jul 2022
Scientific Reports

Volume: 12, P: 1-17

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